ID   U5KLY4_9TRYP            Unreviewed;       356 AA.
AC   U5KLY4;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Threonine aldolase {ECO:0000313|EMBL:AGT02741.1};
DE            EC=4.1.2.5 {ECO:0000313|EMBL:AGT02741.1};
OS   Strigomonas galati.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Strigomonadinae; Strigomonas.
OX   NCBI_TaxID=1003336 {ECO:0000313|EMBL:AGT02741.1};
RN   [1] {ECO:0000313|EMBL:AGT02741.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Alves J.M.P., Klein C., Maia da Silva F., Costa Martins A.G., Serrano M.G.,
RA   Buck G.A., Vasconcelos A.T.R., France-Sagot M., Teixeira M.M.G.,
RA   Motta M.C.M., Camargo E.P.;
RT   "Genomic Cooperation Between Trypanosomatids and Their Bacterial
RT   Endosymbionts in the Synthesis of Essential Amino Acids Heavily Influenced
RT   by Multiple Lateral Gene Transfer Events.";
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SIMILARITY: Belongs to the threonine aldolase family.
CC       {ECO:0000256|ARBA:ARBA00006966}.
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DR   EMBL; KC545211; AGT02741.1; -; Genomic_DNA.
DR   AlphaFoldDB; U5KLY4; -.
DR   GO; GO:0004793; F:threonine aldolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR   InterPro; IPR023603; Low_specificity_L-TA-like.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; NF041359; GntG_guanitoxin; 1.
DR   PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR   PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR   Pfam; PF01212; Beta_elim_lyase; 1.
DR   PIRSF; PIRSF017617; Thr_aldolase; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:AGT02741.1}.
FT   DOMAIN          9..276
FT                   /note="Aromatic amino acid beta-eliminating lyase/threonine
FT                   aldolase"
FT                   /evidence="ECO:0000259|Pfam:PF01212"
FT   MOD_RES         208
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ   SEQUENCE   356 AA;  39247 MW;  51F2AC881C9E02CB CRC64;
     MSEPTHVIDI RSDTVSLPSE AMRQVMAAAE VGDDVYREDP TCIKLEETAA ALVGKEAAVY
     VCSGTMGNLL ACMVYGAQPM TEIIIGQKAH VMRFERGGIN LLGHASTYQI PNDADGKLPL
     ESIREVLSQP PDIHRTLARA VFLENTYNGH VLPHSYVQQV RQLCDEVRDR KVALHCDGAR
     LWNAAIAQNL TMKEVSEPFD SVQCCLSKGL GAPIGGFLAG TKEFVDMARQ FRKMIGGGMR
     QAGIVAAAGL YAMEHNFLRL REDHDNAKLM VRLLQEGLAG YTNNVTIFPT ETNIFFMEFA
     RSVSKETFLA ECKKQNILVS PFNPKGVRIV LNINVTTEDA RHAAKVIIEV LQNLSQ
//