ID U5LLG1_RATTA Unreviewed; 1049 AA.
AC U5LLG1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Toll like receptor 7 {ECO:0000313|EMBL:AGX25593.1};
DE Flags: Fragment;
GN Name=Tlr7 {ECO:0000313|EMBL:AGX25593.1};
OS Rattus tanezumi (Oriental house rat) (Tanezumi rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=35732 {ECO:0000313|EMBL:AGX25593.1};
RN [1] {ECO:0000313|EMBL:AGX25593.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C0477 {ECO:0000313|EMBL:AGX25584.1}, R1831
RC {ECO:0000313|EMBL:AGX25592.1}, R3560 {ECO:0000313|EMBL:AGX25593.1},
RC and R4377 {ECO:0000313|EMBL:AGX25594.1};
RX PubMed=24028551; DOI=10.1186/1471-2148-13-194;
RA Fornuskova A., Vinkler M., Pages M., Galan M., Jousselin E., Cerqueira F.,
RA Morand S., Charbonnel N., Bryja J., Cosson J.F.;
RT "Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and
RT Tlr7) in wild rodents (MURINAE).";
RL BMC Evol. Biol. 13:194-194(2013).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome
CC {ECO:0000256|ARBA:ARBA00004262}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KC811789; AGX25584.1; -; Genomic_DNA.
DR EMBL; KC811797; AGX25592.1; -; Genomic_DNA.
DR EMBL; KC811798; AGX25593.1; -; Genomic_DNA.
DR EMBL; KC811799; AGX25594.1; -; Genomic_DNA.
DR AlphaFoldDB; U5LLG1; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0002218; P:activation of innate immune response; IEA:UniProt.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0001819; P:positive regulation of cytokine production; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR041283; LRR_12.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410:SF2; TOLL-LIKE RECEPTOR 7; 1.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF18837; LRR_12; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 14.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 4.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:AGX25593.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 840..865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 889..1033
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGX25593.1"
SQ SEQUENCE 1049 AA; 121224 MW; D3CCCFC4233DA652 CRC64;
VFPMWTLKRQ SFIFLNMILV SRVLGFRWYP KTLPCDVSLD STNTHVIVDC TDKHLTEIPE
GIPTNTTNLT LTINHIPSIS PDSFHRLNHL EELDLRCNCV PILLGSKANV CTRRLQIRPG
SFSGLSDLKS LYLDGNQLLE IPQDLPSSLQ LLSLEANNIF SITKENLTEL VNIESLYLGQ
NCYYRNPCNV SYSIEKDAFL VMKNLKVLSL KDNNVTAVPT ILPPNLLELY LYNNIIKRIQ
KDDFNKLSQL QVLDLSGNCP RCYNVPYPCT PCENNSPLQI HDNAFDSLTE LKVLRLHSNS
LQHVPAKWFR NMSNLQELDL SQNYLAREIE EAKFLTSLPN LVQLDLSFNY ELQVYHASIT
LPHSLSSLTK LKNLYIKGYV FKELKDSSLS VLHKLPNLEV LDLGTNFIKI ADLNIFQQFE
NLKFIDLSVN KISPSEESRE VGFCPNAQTS VDQHGPQVFD ALHYFRYDEY ARSCRFKNKE
PPTFLPLNAD CHTYGQTLDL SRNNIFFIKP SDFKHLSFLK CLNLSGNAIG QTLNGSELQP
LRELRYLDFS NNRLDLLYST AFEELQNLEI LDLSSNSHYF QAEGITHMLN FTKKLRHLEK
LMMNDNDIST SASRTMESES LRVLEFRGNH LDVLWRDGDN RYLDFFKNLL NLEELDISRN
SLNSLPPGVF EGMPPNLTTL SLAKNGLKSF SWGRLQLLKH LKNLDLSHNQ LTTVPARLAN
CSKSLTKLIL NHNQIRQLTK YFLEDALQLR YLDISSNKIQ VIQKTSFPEN VLNNLNMLLL
HRNRFLCNCD AVWFVWWVNH TDVTIPYLAT DVICAGPGAH KGQSVISLDL YTCELDLTNL
ILFSVSISSV LFLMIVMTTS HLFFWDMWYI YYFWKAKIKG YQHLQSMESC YDAFIVYDTK
NSAVTEWVLQ ELVVKLEDPR EKHFNLCLEE RDWLPGQPVL ENLSQSIQLS RKTVFVMTQK
YAKTESFKMA FYLSHQRLMD EKVDVIILIF LEKPLQKSKF LQLRKRLCSS SVLEWPTNPQ
AHPYFWQCLK NALTTDNHVA YSQMFKETV
//
