ID U5NJ14_TRYBB Unreviewed; 462 AA.
AC U5NJ14;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 13-SEP-2023, entry version 26.
DE SubName: Full=Adenosine transporter 1 {ECO:0000313|EMBL:AGY30950.1};
GN Name=at1 {ECO:0000313|EMBL:AGY30950.1};
OS Trypanosoma brucei brucei.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5702 {ECO:0000313|EMBL:AGY30950.1};
RN [1] {ECO:0000313|EMBL:AGY30950.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=STIB940 {ECO:0000313|EMBL:AGY30949.1}, and STIB950
RC {ECO:0000313|EMBL:AGY30950.1};
RX PubMed=24130910;
RA Graf F.E., Ludin P., Wenzler T., Kaiser M., Brun R., Pyana P.P.,
RA Buscher P., de Koning H.P., Horn D., Maser P.;
RT "Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates
RT Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol.";
RL PLoS Negl. Trop. Dis. 7:E2475-E2475(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR EMBL; KF564954; AGY30949.1; -; Genomic_DNA.
DR EMBL; KF564955; AGY30950.1; -; Genomic_DNA.
DR AlphaFoldDB; U5NJ14; -.
DR SMR; U5NJ14; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR034764; ENT1/ENT2.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00939; 2a57; 1.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF82; TRANSPORTER 2, PUTATIVE-RELATED; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 301..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 236..272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 248..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 50897 MW; 5D948E356E4E7216 CRC64;
MLGFDSANEF IVYVTFLFFG MSVVVVTNSI FSMPFFFIEY YKYAQGKPDA KPEDPKFWKH
MFTYYSIAAF VVELVLASLM LTPIGRRISV TVRLGVGLVI PIVLVFSVMM VTIVTTTETG
AKVTIMLIAI ANGVAMTLCD AGNAALIAPF PTKFYSSVVW GIAVCGVVTS FFSIVIKTSM
EGGYHNMLIQ SRIYFGLVMF MQVISCALLV LLRKNPYAQK YAAEFRYAAR KGIDDKGAGG
DEGNGAAKGP ADQDDDPHGG DDTDKGNVMT ATVDPDTMKD MDQVESITTS QQMLMARVWN
VFWRVWPMLF ACFMVFTTFL VYPAVYFAIK ADTGDGWYLT IAAALFNLGD FLSRLCLQFK
ALHVSPRWVL IGTFARMLLI IPLVLCVRSI ITGPWLPYIL VHAWGFTYGY YGGISQIYAP
RTGSLTTAGE RSLAANWTII SLLGGIFVGA MFALAVNEGL PK
//
