ID   U5P039_HUMAN            Unreviewed;       188 AA.
AC   U5P039;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   08-NOV-2023, entry version 33.
DE   SubName: Full=Runt-related transcription factor 1/NDC1 transmembrane nucleoporin fusion protein {ECO:0000313|EMBL:AGY36885.1};
GN   Name=RUNX1 {ECO:0000313|EMBL:AGY36885.1};
GN   Synonyms=TMEM48 fusion {ECO:0000313|EMBL:AGY36885.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AGY36885.1};
RN   [1] {ECO:0000313|EMBL:AGY36885.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Rodriguez-Perales S., Cigudosa J.C.;
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; KF305770; AGY36885.1; -; Genomic_RNA.
DR   AlphaFoldDB; U5P039; -.
DR   SMR; U5P039; -.
DR   MaxQB; U5P039; -.
DR   ChiTaRS; RUNX1; human.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR   Gene3D; 2.60.40.720; -; 1.
DR   InterPro; IPR000040; AML1_Runt.
DR   InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR   InterPro; IPR012346; p53/RUNT-type_TF_DNA-bd_sf.
DR   InterPro; IPR013524; Runt_dom.
DR   PANTHER; PTHR11950; RUNT RELATED; 1.
DR   PANTHER; PTHR11950:SF40; RUNT-RELATED TRANSCRIPTION FACTOR 1; 1.
DR   Pfam; PF00853; Runt; 1.
DR   PRINTS; PR00967; ONCOGENEAML1.
DR   SUPFAM; SSF49417; p53-like transcription factors; 1.
DR   PROSITE; PS51062; RUNT; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000313|EMBL:AGY36885.1};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Transmembrane {ECO:0000313|EMBL:AGY36885.1}.
FT   DOMAIN          50..178
FT                   /note="Runt"
FT                   /evidence="ECO:0000259|PROSITE:PS51062"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   188 AA;  20395 MW;  D2B706A902D72B2A CRC64;
     MRIPVDASTS RRFTPPSTAL SPGKMSEALP LGAPDAGAAL AGKLRSGDRS MVEVLADHPG
     ELVRTDSPNF LCSVLPTHWR CNKTLPIAFK VVALGDVPDG TLVTVMAGND ENYSAELRNA
     TAAMKNQVAR FNDLRFVGRS GRGKSFTLTI TVFTNPPQVA TYHRAIKITV DGPREPRNSL
     TWPRYPHI
//