ID U5PZB3_CRAGI Unreviewed; 697 AA.
AC U5PZB3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Toll-like receptor 4 {ECO:0000313|EMBL:AGY49098.1};
GN Name=TLR4 {ECO:0000313|EMBL:AGY49098.1};
OS Crassostrea gigas (Pacific oyster) (Crassostrea angulata).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Ostreida; Ostreoidea; Ostreidae; Crassostrea.
OX NCBI_TaxID=29159 {ECO:0000313|EMBL:AGY49098.1};
RN [1] {ECO:0000313|EMBL:AGY49098.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24098508;
RA Zhang Y., He X., Yu F., Xiang Z., Li J., Thorpe K.L., Yu Z.;
RT "Characteristic and Functional Analysis of Toll-like Receptors (TLRs) in
RT the lophotrocozoan, Crassostrea gigas, Reveals Ancient Origin of TLR-
RT Mediated Innate Immunity.";
RL PLoS ONE 8:E76464-E76464(2013).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; KC700620; AGY49098.1; -; mRNA.
DR RefSeq; NP_001295828.1; NM_001308899.1.
DR AlphaFoldDB; U5PZB3; -.
DR GeneID; 105325742; -.
DR KEGG; crg:105325742; -.
DR CTD; 7099; -.
DR OrthoDB; 2971232at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 2.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:AGY49098.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..697
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004663498"
FT TRANSMEM 502..523
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 553..692
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 697 AA; 80036 MW; 3C72506DEB57910F CRC64;
MKYLRTLTVF LLLAIHTCTP DEMASASHCP DSVCFCRVLD TADCSYRNLS NIPRGLPASI
RSLVMSGNPL YSLSDDFFRP VENLTLKNLA LDKCNIFRIS TFTLEPLRSL EMLDLSSNKL
YNAMLDKCTE KLGYSTLKVL NLSGNSLYTL DAIYNFLENK WFSNLTDLIM QQSQVRKVEM
KSLKNLLFLQ TLDLSQNAIE QFSSYGLPTL KTLDLSSNSL PEFPRPCNGL NNPFYPKLEN
LLLRRNRISE TYLLEDYGHC LTALVKLDLS LNPIKIILPF AFVYFKDLTY LYLEQLLGVI
EVNKFAFATL NLRELSIGNT VKGYMNVVDF YTFLLYNPFL KILSLNNINL SLVNTSRMLS
KLTNLTSLSI LNCNIQNVPT LTNPPLLSSI DMSFNSIQSL HAEAFQFLGK LKYISLKSNA
LTSVTLESLP RVLWDTSDVL IDLSSNPFDC VCSLEWFKFW YENNMKRTSG NASLYICNTP
TQWQEVPLVD FDTADCHELN QYVVMALIIA GELCLVALSF IVVRIYRWDI KYYIHACKYN
KLTSPPENLR DDFLYDGFVA YNTRGRKWIM AELVEHVERK HNYKLCLHER DIIPGGVYVE
DVLESIDFSR KFILVLSNNF MDDQWGRYET AIASHTLAEG GGGKLFLILL EDIRSEYITR
SLKVLLKSIR HAEWTKNKNG QKIFWNNVVQ NLEKSEK
//
