ID U5RX68_9CLOT Unreviewed; 507 AA.
AC U5RX68;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Cardiolipin synthase {ECO:0000313|EMBL:AGY77187.1};
GN Name=cls {ECO:0000313|EMBL:AGY77187.1};
GN ORFNames=CAETHG_2984 {ECO:0000313|EMBL:AGY77187.1};
OS Clostridium autoethanogenum DSM 10061.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=1341692 {ECO:0000313|EMBL:AGY77187.1, ECO:0000313|Proteomes:UP000017590};
RN [1] {ECO:0000313|EMBL:AGY77187.1, ECO:0000313|Proteomes:UP000017590}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10061 {ECO:0000313|EMBL:AGY77187.1};
RX PubMed=24655715; DOI=10.1186/1754-6834-7-40;
RA Brown S.D., Nagaraju S., Utturkar S., De Tissera S., Segovia S.,
RA Mitchell W., Land M.L., Dassanayake A., Kopke M.;
RT "Comparison of single-molecule sequencing and hybrid approaches for
RT finishing the genome of Clostridium autoethanogenum and analysis of CRISPR
RT systems in industrial relevant Clostridia.";
RL Biotechnol. Biofuels 7:40-40(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP006763; AGY77187.1; -; Genomic_DNA.
DR RefSeq; WP_023162942.1; NZ_CP012395.1.
DR AlphaFoldDB; U5RX68; -.
DR KEGG; cah:CAETHG_2984; -.
DR PATRIC; fig|1341692.11.peg.2991; -.
DR HOGENOM; CLU_038053_1_2_9; -.
DR Proteomes; UP000017590; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR CDD; cd09154; PLDc_SMU_988_like_1; 1.
DR CDD; cd09160; PLDc_SMU_988_like_2; 1.
DR Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR InterPro; IPR022924; Cardiolipin_synthase.
DR InterPro; IPR027379; CLS_N.
DR InterPro; IPR025202; PLD-like_dom.
DR InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR Pfam; PF13091; PLDc_2; 2.
DR Pfam; PF13396; PLDc_N; 1.
DR SMART; SM00155; PLDc; 2.
DR SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR PROSITE; PS50035; PLD; 2.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 70..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 243..270
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
FT DOMAIN 420..447
FT /note="PLD phosphodiesterase"
FT /evidence="ECO:0000259|PROSITE:PS50035"
SQ SEQUENCE 507 AA; 59347 MW; 01531C84F76CDA32 CRC64;
MGERRIFVAV FKFVILIFWT MFQFVAIALV FNSFNISLIY YFVFFEIISV IFVIHLNYKD
KNTSYKISWI VLILLIPVVG ALIYIFSMIG IKRNFNKINK IELDKDVFPK EDQDMLSSFK
NENKMRYNET RLIKNISDYG CYINTKVDYF SSGEDMYKKL LEELKNAKKF IFLEYFIISK
SKMWDEIFEI LKEKANNGVE VRVLVDYVGS LVVLPKNFKR SLKVNNIKLK IFNPFKIILN
FMLNYRDHRK ITVIDGTVAF TGGINIGDEY INEYKKYGYW KDMAVCLKGE AVYSFTIMFL
RMWQSISKKK EDFSKYKTSF KLEKSQGIVM PYNSGPIKPD GAAEYVYLNI INSAKNYIYI
TTPYLVIGYE MTLALCLAAK RGVDVRIITP FIPDKKIVQI LTRSHYDNLL DSGVKIYEYT
PGFIHGKTFV SDGECAVVGT INLDYRSLYL HFECATYLYN VPIIDNIYKD FLRTIEVSKK
INKDVWEKRS LSKKIVESIL RMFAPLV
//
