ID U5T1Z8_9GAMM Unreviewed; 284 AA.
AC U5T1Z8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0008006|Google:ProtNLM};
GN ORFNames=SPICUR_01305 {ECO:0000313|EMBL:AGY91281.1};
OS Spiribacter curvatus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC Ectothiorhodospiraceae; Spiribacter.
OX NCBI_TaxID=1335757 {ECO:0000313|EMBL:AGY91281.1, ECO:0000313|Proteomes:UP000017640};
RN [1] {ECO:0000313|EMBL:AGY91281.1, ECO:0000313|Proteomes:UP000017640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAH-SP71 {ECO:0000313|EMBL:AGY91281.1,
RC ECO:0000313|Proteomes:UP000017640};
RX PubMed=24225341; DOI=10.1186/1471-2164-14-787;
RA Lopez-Perez M., Ghai R., Leon M.J., Rodriguez-Olmos A., Copa-Patino J.L.,
RA Soliveri J., Sanchez-Porro C., Ventosa A., Rodriguez-Valera F.;
RT "Genomes of "Spiribacter", a streamlined, successful halophilic
RT bacterium.";
RL BMC Genomics 14:787-787(2013).
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DR EMBL; CP005990; AGY91281.1; -; Genomic_DNA.
DR AlphaFoldDB; U5T1Z8; -.
DR STRING; 1335757.SPICUR_01305; -.
DR KEGG; spiu:SPICUR_01305; -.
DR PATRIC; fig|1335757.3.peg.256; -.
DR eggNOG; COG2084; Bacteria.
DR HOGENOM; CLU_035117_1_0_6; -.
DR Proteomes; UP000017640; Chromosome.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR43060:SF15; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000017640}.
FT DOMAIN 1..148
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 152..271
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 158
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 284 AA; 29931 MW; 46E7B70188969B99 CRC64;
MGRGMARNLS AAGLLAGVWN RTRANGEALA EELQVPLTED AAALARLCDV VITCVSADQD
VREVVGALAD GVSKGDVVID TSTIGVDTAE AAAETLRARG AEFLDAPVTG GPEGADTGTL
QIMVGGDPDV LERIRPALQA IGSGATHFGP VGYGQRAKAV NQVMVAGLVQ AISESLSFAE
ASGLDTERLL PVLTGGAAGS RLLERRGSRI LAGDFEPGFR VSLHHKDLNL CRDLLQKLDV
SLPLVEMTIK HYERLLEQGY GEEDTSALFR LKRDLFASGN RKSL
//
