ID U5T9R6_COWPX Unreviewed; 242 AA.
AC U5T9R6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Host range factor p28 {ECO:0000256|ARBA:ARBA00039653};
DE AltName: Full=E3 ubiquitin-protein ligase p28 {ECO:0000256|ARBA:ARBA00034917};
GN Name=CPXV023 {ECO:0000313|EMBL:AGY97555.1};
OS Cowpox virus (CPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10243 {ECO:0000313|EMBL:AGY97555.1, ECO:0000313|Proteomes:UP000168833};
OH NCBI_TaxID=10129; Apodemus sylvaticus (European woodmouse).
OH NCBI_TaxID=9913; Bos taurus (Bovine).
OH NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH NCBI_TaxID=10090; Mus musculus (Mouse).
OH NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN [1] {ECO:0000313|EMBL:AGY97555.1, ECO:0000313|Proteomes:UP000168833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HumLit08/1 {ECO:0000313|EMBL:AGY97555.1};
RA Dabrowski P.W., Radonic A., Kurth A., Nitsche A.;
RT "Genome-wide comparison of cowpoxviruses reveals a new clade related to
RT Variola virus.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: RING-finger E3 ubiquitin ligase which catalyzes the formation
CC of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Plays an
CC important role in virulence by acting as an anti-apoptotic factor.
CC {ECO:0000256|ARBA:ARBA00025051}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Host
CC cytoplasm {ECO:0000256|ARBA:ARBA00004192}.
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG021 family.
CC {ECO:0000256|ARBA:ARBA00034749}.
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DR EMBL; KC813493; AGY97555.1; -; Genomic_DNA.
DR Proteomes; UP000168833; Genome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0039648; P:modulation by symbiont of host protein ubiquitination; IEA:UniProtKB-KW.
DR GO; GO:0039526; P:perturbation by virus of host apoptosis; IEA:UniProtKB-KW.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016398; E3_ubiquitin-prot_ligase_p28.
DR InterPro; IPR018004; KilA/APSES_HTH.
DR InterPro; IPR017880; KilA_N.
DR InterPro; IPR045072; MKRN-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR11224; MAKORIN-RELATED; 1.
DR PANTHER; PTHR11224:SF10; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF04383; KilA-N; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR PIRSF; PIRSF003775; E3_ubiquit_lig_p28; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51301; KILA_N; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00023323};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Modulation of host cell apoptosis by virus {ECO:0000256|ARBA:ARBA00023323};
KW Modulation of host ubiquitin pathway by viral E3 ligase
KW {ECO:0000256|ARBA:ARBA00022711};
KW Modulation of host ubiquitin pathway by virus
KW {ECO:0000256|ARBA:ARBA00022662};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 21..131
FT /note="KilA-N"
FT /evidence="ECO:0000259|PROSITE:PS51301"
FT DOMAIN 173..226
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 242 AA; 28633 MW; 12C09D2D4F0E629F CRC64;
MEFDPTKINT SSIDHVTILQ YIDEPNDIRL TVCIIQNINN ITYYINITKI NPHLANQFRA
WKKRIAGRDY MTNLSRDTGI QQSKLTETIR NCQKNRNIYG LYIHYNLVIN VVIDWIADVI
IQSILRGLVN WYITNHHYSP NTPNNTTIIS ELDIIKILDK YEEVYRVSKE KECGICYEVV
YSKQLENDRY FGLLDSCNHI FCITCINIWH RTRRETGASD NCPICRTRFR NITMSKFYKF
VN
//
