ID U5U2C4_SIV Unreviewed; 729 AA.
AC U5U2C4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AGZ16601.1};
OS Simian immunodeficiency virus (SIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AGZ16601.1};
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGZ16601.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SIVmac251 {ECO:0000313|EMBL:AGZ16601.1};
RX PubMed=24146859;
RA Fieni F., Stone M., Ma Z.M., Dutra J., Fritts L., Miller C.J.;
RT "Viral RNA Levels and env Variants in Semen and Tissues of Mature Male
RT Rhesus Macaques Infected with SIV by Penile Inoculation.";
RL PLoS ONE 8:E76367-E76367(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; KF523489; AGZ16601.1; -; mRNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 2: Evidence at transcript level;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AGZ16601.1};
KW Virion {ECO:0000313|EMBL:AGZ16601.1}.
FT TRANSMEM 463..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..461
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 479..674
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 50..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 573..600
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 662..677
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGZ16601.1"
FT NON_TER 729
FT /evidence="ECO:0000313|EMBL:AGZ16601.1"
SQ SEQUENCE 729 AA; 83912 MW; F9FAEF55ABC6A6CF CRC64;
ESFDAWENTV TEQAIEDVWQ LFETSIKPCV KLSPLCITMR CNKSETDKWG LTKSSTTTTA
TTATPASTTR TTSAKIDMVN ETSSCITHNN CTGLEQEQMI SCKFNMTGLK RDKKKEYNET
WYSTDLVCEQ GNSTDNECRC YMNHCNTSVI QESCDKHYWD TIRFRYCAPP GYALLRCNDT
NYSGFMPKCS KVVVSSCTRM METQTSTWFG FNGTRAENRT YIYWHGRDNR TIISLNKYYN
LTMKCRRPGN KTVLPITIMS GLVFHSQPIN DRPKQAWCWF GGNWKDAIKE VKQTIVKHPR
YTGTNNTDKI NLTAPRGGDP EVTFMWTNCR GEFLYCNMNW FLNWVEDRNL TLTTQKLRER
HKRNYVPCHI RQIINTWHKV GKNVYLPPRE GDLTCNSTVT SLIANIDWTD GNQTNITMSA
EVAELYRLEL GDYKLVEITP IGLAPTDVKR YTTGGTSRNK RGVFVLGFLG FLATAGSAMG
AASLTLTAQS RTLLAGIVQQ QQQLLDVVKR QQELLRLTVW GTKNLQTRVT AIEKYLKDQA
QLNAWGCAFR QVCHTTVPWP NASLTPDWNN DTWQEWERKV DFLEENITAL LEEAQIQQEK
NMYELQKLNS WDVFGNWFDL ASWIRYIQYG IYIVVGVILL RIVIYIVQML AKLRQGYRPV
FSSPPSYSQQ IHTQQDPALP TREGKEGDGG EGGGNSSWPW QIEYIHFLIR QLIRLLTWLF
SNCRTLLSR
//
