ID U5U8U2_9EUTH Unreviewed; 185 AA.
AC U5U8U2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|RuleBase:RU364086};
DE Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE Flags: Fragment;
GN Name=BDNF {ECO:0000313|EMBL:AGZ19889.1};
OS Uropsilus sp. 2 TW-2013.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Eulipotyphla; Talpidae; Uropsilus.
OX NCBI_TaxID=1415661 {ECO:0000313|EMBL:AGZ19889.1};
RN [1] {ECO:0000313|EMBL:AGZ19889.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24161152; DOI=10.1186/1471-2148-13-232;
RA Wan T., He K., Jiang X.L.;
RT "Multilocus phylogeny and cryptic diversity in Asian shrew-like moles
RT (Uropsilus, Talpidae): implications for taxonomy and conservation.";
RL BMC Evol. Biol. 13:232-232(2013).
CC -!- FUNCTION: During development, promotes the survival and differentiation
CC of selected neuronal populations of the peripheral and central nervous
CC systems. Participates in axonal growth, pathfinding and in the
CC modulation of dendritic growth and morphology. Major regulator of
CC synaptic transmission and plasticity at adult synapses in many regions
CC of the CNS. {ECO:0000256|RuleBase:RU364086}.
CC -!- FUNCTION: Important signaling molecule that activates signaling
CC cascades downstream of NTRK2 (By similarity). During development,
CC promotes the survival and differentiation of selected neuronal
CC populations of the peripheral and central nervous systems. Participates
CC in axonal growth, pathfinding and in the modulation of dendritic growth
CC and morphology. Major regulator of synaptic transmission and plasticity
CC at adult synapses in many regions of the CNS. The versatility of BDNF
CC is emphasized by its contribution to a range of adaptive neuronal
CC responses including long-term potentiation (LTP), long-term depression
CC (LTD), certain forms of short-term synaptic plasticity, as well as
CC homeostatic regulation of intrinsic neuronal excitability.
CC {ECO:0000256|ARBA:ARBA00025383}.
CC -!- SUBUNIT: Monomers and homodimers (By similarity). Binds to NTRK2/TRKB.
CC Can form heterodimers with other neurotrophin family members, such as
CC NTF3 and NTF4 (in vitro), but the physiological relevance of this is
CC not clear (By similarity). BDNF precursor form: interacts with the
CC heterodimer formed by NGFR and SORCS2. Mature BDNF has much lower
CC affinity for the heterodimer formed by NGFR and SORCS2.
CC {ECO:0000256|ARBA:ARBA00025882}.
CC -!- SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB.
CC {ECO:0000256|RuleBase:RU364086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC -!- SIMILARITY: Belongs to the NGF-beta family.
CC {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR EMBL; KF778011; AGZ19888.1; -; Genomic_DNA.
DR EMBL; KF778012; AGZ19889.1; -; Genomic_DNA.
DR EMBL; KF778013; AGZ19890.1; -; Genomic_DNA.
DR EMBL; KF778014; AGZ19891.1; -; Genomic_DNA.
DR EMBL; KF778015; AGZ19892.1; -; Genomic_DNA.
DR AlphaFoldDB; U5U8U2; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01912; BDNFACTOR.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|RuleBase:RU364086}.
FT DOMAIN 121..185
FT /note="Nerve growth factor-related"
FT /evidence="ECO:0000259|SMART:SM00140"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGZ19889.1"
FT NON_TER 185
FT /evidence="ECO:0000313|EMBL:AGZ19889.1"
SQ SEQUENCE 185 AA; 20535 MW; 1B66C0DC930D8A7C CRC64;
YFGCMKAAPM KEASVRGPGS LAYPGVRTHG TLESVNGPKA GSRGLTLADT FEHVIEELLD
EDQKVRPHEE NNKDADLYTS RVMLSSQVPL EPPLLFLLEE YKNYLDAANM SMRVRRHSDP
ARRGELSVCD SISEWVTAAD KKTAVDMSGG TVTVLEKVPV SKGQLKQYFY ETKCNPMGYT
KEGCR
//
