ID   U5VQ28_9ACTN            Unreviewed;       281 AA.
AC   U5VQ28;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   SubName: Full=Putative short-chain dehydrogenase {ECO:0000313|EMBL:AGZ38914.1};
GN   ORFNames=AFR_03125 {ECO:0000313|EMBL:AGZ38914.1};
OS   Actinoplanes friuliensis DSM 7358.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ38914.1, ECO:0000313|Proteomes:UP000017746};
RN   [1] {ECO:0000313|EMBL:AGZ38914.1, ECO:0000313|Proteomes:UP000017746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ38914.1,
RC   ECO:0000313|Proteomes:UP000017746};
RX   PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA   Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA   Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT   "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT   HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL   J. Biotechnol. 178:41-42(2014).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|ARBA:ARBA00006484}.
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DR   EMBL; CP006272; AGZ38914.1; -; Genomic_DNA.
DR   AlphaFoldDB; U5VQ28; -.
DR   STRING; 1246995.AFR_03125; -.
DR   KEGG; afs:AFR_03125; -.
DR   PATRIC; fig|1246995.3.peg.629; -.
DR   eggNOG; COG0300; Bacteria.
DR   HOGENOM; CLU_010194_2_1_11; -.
DR   Proteomes; UP000017746; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd05233; SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR44196; DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7B; 1.
DR   PANTHER; PTHR44196:SF5; POSSIBLE MULTI-FUNCTIONAL ENZYME WITH ACYL-COA-REDUCTASE ACTIVITY ACRA1; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PIRSF; PIRSF000126; 11-beta-HSD1; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   SMART; SM00822; PKS_KR; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017746}.
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          261..281
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  29678 MW;  0376D48862C8B0CC CRC64;
     MPGTPSGPNE EGNTMTTPTG RDFAVVTGAS SGIGYELARQ FAENGFDLLL AAEDEGITQA
     AADLRRDGVN DVQAVQVDLA TYDGVEELYA AIRAAGRPVD AIAINAGRGI GGDFTRQTDL
     SDELNVIDLN VRSTVHLAKR VLPDLVSRGA GRVLFTSSIA STMPGTYQAV YNASKSFVQS
     FAEALRNELK DTGVTVTSLM PGPTDTNFFD RAEMEDTKVG ASKKDDPAQV AEQGFKALMK
     GEEKVVAGSL KTKVQGAASK VMPDSVKAQM HRKMAEPGSA E
//