ID   U5W858_9ACTN            Unreviewed;       794 AA.
AC   U5W858;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=Signaling protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AFR_35365 {ECO:0000313|EMBL:AGZ45329.1};
OS   Actinoplanes friuliensis DSM 7358.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ45329.1, ECO:0000313|Proteomes:UP000017746};
RN   [1] {ECO:0000313|EMBL:AGZ45329.1, ECO:0000313|Proteomes:UP000017746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ45329.1,
RC   ECO:0000313|Proteomes:UP000017746};
RX   PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA   Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA   Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT   "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT   HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL   J. Biotechnol. 178:41-42(2014).
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DR   EMBL; CP006272; AGZ45329.1; -; Genomic_DNA.
DR   RefSeq; WP_023561665.1; NC_022657.1.
DR   AlphaFoldDB; U5W858; -.
DR   STRING; 1246995.AFR_35365; -.
DR   KEGG; afs:AFR_35365; -.
DR   PATRIC; fig|1246995.3.peg.7156; -.
DR   eggNOG; COG5001; Bacteria.
DR   HOGENOM; CLU_000445_91_5_11; -.
DR   OrthoDB; 9763119at2; -.
DR   Proteomes; UP000017746; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR   GO; GO:0007165; P:signal transduction; IEA:UniProt.
DR   CDD; cd01948; EAL; 1.
DR   CDD; cd01949; GGDEF; 1.
DR   Gene3D; 3.30.70.270; -; 1.
DR   Gene3D; 3.30.450.350; CHASE domain; 1.
DR   Gene3D; 3.20.20.450; EAL domain; 1.
DR   InterPro; IPR006189; CHASE_dom.
DR   InterPro; IPR042240; CHASE_sf.
DR   InterPro; IPR001633; EAL_dom.
DR   InterPro; IPR035919; EAL_sf.
DR   InterPro; IPR000160; GGDEF_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   NCBIfam; TIGR00254; GGDEF; 1.
DR   PANTHER; PTHR33121; CYCLIC DI-GMP PHOSPHODIESTERASE PDEF; 1.
DR   PANTHER; PTHR33121:SF85; CYCLIC DI-GMP PHOSPHODIESTERASE PDEK-RELATED; 1.
DR   Pfam; PF03924; CHASE; 1.
DR   Pfam; PF00563; EAL; 1.
DR   Pfam; PF00990; GGDEF; 1.
DR   SMART; SM00052; EAL; 1.
DR   SMART; SM00267; GGDEF; 1.
DR   SUPFAM; SSF141868; EAL domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50883; EAL; 1.
DR   PROSITE; PS50887; GGDEF; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        306..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          397..530
FT                   /note="GGDEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50887"
FT   DOMAIN          539..787
FT                   /note="EAL"
FT                   /evidence="ECO:0000259|PROSITE:PS50883"
SQ   SEQUENCE   794 AA;  85389 MW;  DE960E7CAB6E1363 CRC64;
     MRSTSLGSNR RRWSGVALVV VVALLGTAVA WVATGNARRA EQRYAAQLMD RYTSDLTRAI
     TTEIQRYGDT LDDVATALGA QTDLTADDFG WITNKISNRR LPGATSLGFV VSTPDSGVGA
     LQSYWRERGA SNLMLSPVDT AGEHAFAVFT RSFDGVPVVA GMDLSAAPEA SDALQDAQFL
     GGFAVSRAYV LLKDRALPVT QQQLSFLFAV PVYRIGGAFR GWLTMGVHGR DLLTETLRTQ
     SHGAVTAGLE DPTDRVERTI ASASGGKARN YPAALDRTAS VSAGLRTWRL EVHPTDQLLE
     ETDRGIVGTT FAVAMTITLL LTLLVALLAG ARNRAMSKVD AATAALRSDI ERRQQVETRL
     RERELELEQM ALHDPLTGLA NRAGLDARLA EVVGTRSDVA LLLIDLDDFK LVNDAYGHAA
     GDAMLTEFAQ VLLAGVRTGD VAARIGGDEF VVLITDVPDD ARAVAAAQRV LAAAASAPVR
     LGDDTLPVRA SIGVATSRAG DSPKELLRRA DIAMYQAKHL GTHGVQLHDP SMTDRRKADS
     LLAEDLAGAL DRDELHVLYQ PLVDLTDSRP IGVEALIRWR HPRLGLVSPA DFIPIAERTG
     TITAIGLWVL ETACREITRW DGLYVSVNLS PRQLQEPTLV QDVLGVLART GLAPDRLVLE
     ITESALVDES AGIAMLQEFR EHGIRVAIDD FGTGYSSLHY LTRLPVDILK IDRSFVAELN
     GTPEGSGITE AILRLSQVLH LTAIAEGIET AEQAAELQLL GCGVGQGYLF ARPLPPTELQ
     DLLLSPSPRP SSLS
//