ID U5WEN1_9ACTN Unreviewed; 544 AA.
AC U5WEN1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Major facilitator superfamily protein {ECO:0000313|EMBL:AGZ46406.1};
GN ORFNames=AFR_40760 {ECO:0000313|EMBL:AGZ46406.1};
OS Actinoplanes friuliensis DSM 7358.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1246995 {ECO:0000313|EMBL:AGZ46406.1, ECO:0000313|Proteomes:UP000017746};
RN [1] {ECO:0000313|EMBL:AGZ46406.1, ECO:0000313|Proteomes:UP000017746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 7358 {ECO:0000313|EMBL:AGZ46406.1,
RC ECO:0000313|Proteomes:UP000017746};
RX PubMed=24637369; DOI=10.1016/j.jbiotec.2014.03.011;
RA Ruckert C., Szczepanowski R., Albersmeier A., Goesmann A., Fischer N.,
RA Steinkamper A., Puhler A., Biener R., Schwartz D., Kalinowski J.;
RT "Complete genome sequence of the actinobacterium Actinoplanes friuliensis
RT HAG 010964, producer of the lipopeptide antibiotic friulimycin.";
RL J. Biotechnol. 178:41-42(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP006272; AGZ46406.1; -; Genomic_DNA.
DR AlphaFoldDB; U5WEN1; -.
DR STRING; 1246995.AFR_40760; -.
DR KEGG; afs:AFR_40760; -.
DR PATRIC; fig|1246995.3.peg.8251; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_033995_0_0_11; -.
DR Proteomes; UP000017746; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17474; MFS_YfmO_like; 1.
DR Gene3D; 3.40.50.12370; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR001958; Tet-R_TetA/multi-R_MdtG-like.
DR InterPro; IPR006016; UspA.
DR PANTHER; PTHR43683; MULTIDRUG EFFLUX PROTEIN YFMO; 1.
DR PANTHER; PTHR43683:SF1; MULTIDRUG EFFLUX PROTEIN YFMO; 1.
DR Pfam; PF07690; MFS_1; 2.
DR Pfam; PF00582; Usp; 1.
DR PRINTS; PR01035; TCRTETA.
DR SUPFAM; SSF52402; Adenine nucleotide alpha hydrolases-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 33..55
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 151..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 193..213
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..307
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..336
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..368
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 544 AA; 55790 MW; DCBF148B919547BD CRC64;
MAFACVISFM GIGLVDPILP ALATDLHASP SQVSLLFTSY LVVTAVAMLV VGAVASRIGP
KRTLVVGLSI IVVFAALAGT SGTVGQIVGF RAGWGLGNAL FIATSLAVIV ASASGGFAGA
IILYETALGL GIAVGPLLGG ELGSISWRGP FYGVAVLMAL AMVATIVFVP ALPKPEKPTS
ITAPLKALRH RGLLTMGIMA LLYNWGFFTM LGYAPYPMEL DAHKLGLVFT AWGLLVAAFS
VFFAPRLQAR FGTAKVLYAN LLALAVVMVV IAAGVSTPAT VIAAVIVSGA FIGINNTLTT
QAVMLVAPVE RSVASSAYGF VRFIGGGLAP FVAGKLADRF DLSVPFYLGG VAFLLAIVVL
STGHKLVTAA EQDESPLQPV GALTPADARP VVVAVGAAPD APEIVAAAAA IARASGSPLE
VVRVRETVVI EELAIEPEDE QDARAAVEGH LRRLADHGIA ATGLLLTSVG DHAAAGRALA
RHAEDVQART VAVGRSPRGP AVQFADGSFT SALTHSTTRT VVLVTPDETP HPLTAATLHE
LRGV
//
