ID U5WLK8_MYCKA Unreviewed; 959 AA.
AC U5WLK8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:AGZ49852.1};
GN ORFNames=MKAN_05840 {ECO:0000313|EMBL:AGZ49852.1};
OS Mycobacterium kansasii ATCC 12478.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=557599 {ECO:0000313|EMBL:AGZ49852.1, ECO:0000313|Proteomes:UP000017786};
RN [1] {ECO:0000313|EMBL:AGZ49852.1, ECO:0000313|Proteomes:UP000017786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12478 {ECO:0000313|EMBL:AGZ49852.1,
RC ECO:0000313|Proteomes:UP000017786};
RG McGill University Mycobacterium genome consortium;
RA Veyrier F.J., Behr M.A.;
RT "Genome sequence of Mycobacterium kansasii.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP006835; AGZ49852.1; -; Genomic_DNA.
DR RefSeq; WP_023366044.1; NC_022663.1.
DR AlphaFoldDB; U5WLK8; -.
DR GeneID; 29702070; -.
DR KEGG; mkn:MKAN_05840; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_3_2_11; -.
DR OrthoDB; 4747874at2; -.
DR Proteomes; UP000017786; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 762..780
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 787..812
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..884
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..924
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 220..347
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT COILED 505..532
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 959 AA; 104219 MW; ECBC8EA53991B5C4 CRC64;
MSDKHGHRIS LSGTIRRLSV PILLFWVALA AITNIAVPRL EIVAEAHNVA LSSADAPSLQ
AMKRIGKVFR EYNSDSAAMI VLEGNEPLGD EAHRYYDTLI DKLSQDTKHV EHVQDFWGDP
LTAAGVQSTD GKAAYVQVYL AGNQGEALAN ESVAAVRDIV AHTPPPNRMK AYVTGAAPLL
ADQFGVGSKG TVKVTLITLL VIAVMLFFVY RSVVTMFLVL LTVLVQLLAA RGIIALLADS
GIIGLSVYAT NLLTLLVIAA GTDYAIFFVG RYQEARGTGE DQGTAFHTMF HGTAHIVLGS
GLTIAGAVYC LSFTRLPYFQ SLGVPVAIGI LVALTAALTL TPAVLTIGSH FGLFEPKRKM
RTRGWRRIGT AIVRWPGPIL TVACAVALIG LLALPGYQTS YDVRHYIPAS APANIGYAAA
ERHFSPARLN PDLLMIETDH DMRNPADMLV LDRIARAVFH LPGIAQVQSI TRPLGSPIDH
SSIPFQISMQ NTGQVMNLKY QQDRAADMLK QADELARSIE ILKRQYALQQ QLAAATHEQA
VSFHETAATL TELRDKIANL DDFLRPIRSY FYWEQHCYDI PACWAARSAF DAIDGIDRLS
DQLESVRKTL DKLDAIQPQL LALIPDQIAS QQANHDLTLS NYSTISGIYD QTAAMTENST
AMGQAFDAAK NDDFFYLPPE AFNNPDFKRG LQMFLSPDGK AARMIISHEG DPATPEGISH
VDPIKKAARE AVKGTPLQAS KIYLAGTAPT YKDIQDGAKY DLMIAGIAAL SLILLIMMIV
TRSLVAAIVI VGTVALSLGA SFGLSVLVWQ HIFGIQLYWI VLALAVIVLL GVGSDYNLLL
ISRLKEEIGA GLNTGIIRAM GGSGGVVTAA GLVFAATMSS FVFSDLRVLG QIGTTIGLGL
LFDTLIVRSF MTPSIAALLG RWFWWPQRVR PRPASRMLRP YGPRRLVRKL LLREAQEMG
//
