ID U5WP55_MYCKA Unreviewed; 543 AA.
AC U5WP55;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Adenylyl cyclase {ECO:0000313|EMBL:AGZ51013.1};
GN ORFNames=MKAN_12635 {ECO:0000313|EMBL:AGZ51013.1};
OS Mycobacterium kansasii ATCC 12478.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=557599 {ECO:0000313|EMBL:AGZ51013.1, ECO:0000313|Proteomes:UP000017786};
RN [1] {ECO:0000313|EMBL:AGZ51013.1, ECO:0000313|Proteomes:UP000017786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12478 {ECO:0000313|EMBL:AGZ51013.1,
RC ECO:0000313|Proteomes:UP000017786};
RG McGill University Mycobacterium genome consortium;
RA Veyrier F.J., Behr M.A.;
RT "Genome sequence of Mycobacterium kansasii.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
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DR EMBL; CP006835; AGZ51013.1; -; Genomic_DNA.
DR AlphaFoldDB; U5WP55; -.
DR KEGG; mkn:MKAN_12635; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG3850; Bacteria.
DR HOGENOM; CLU_025433_2_0_11; -.
DR Proteomes; UP000017786; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 37..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..232
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 252..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 272..324
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 356..480
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 543 AA; 58093 MW; 92140A86F4C6F76B CRC64;
MSFRPVTTAG YGGLVATVAA LPGRISAFAR WVVRTPWPVF SLSMLQSDII GALFVLGFLR
YGLPPGDRIQ LQDLPRLNLV IFVLSAHVVF FAGVAANFKL LVPVFRWQRR DNLLAEADPA
ATELARRRVL RMPFYRTVVS LVVWAIGSAV FIVASWSVAR YAAPVVAVAT ALGATATAII
GYLQSERVLR PVAVAALRSG VPENLRTPGV ILRLMLAWVL STAVPLLAIV LAVVSDKIAL
LHTAPEKLFD PILLLALAAL GIGFVSTLLV AMSIADPLRQ LRWALSEVQR GNYNAHMQIY
DASELGLLQA GFNDMVRDLS ERQRLRDLFG RYVGEDVARR AIERGTELGG QERDVAVLFV
DLVGSTQLAA TRPPAEVVHL LNEFFRVVVD TVGRHGGFVN KFQGDAALAI FGAPIEHPDG
AGAALCAARE LHDALIPVLG SAEFGIGVSA GRAIAGHIGA QARFEYTVIG DPVNEAARLT
ELAKLEAGHV LASAIAVSGA LDAEALCWDV AEVVELRGRA APTQLARPLN LAAPEEVSSE
MGS
//
