ID U5WQN7_MYCKA Unreviewed; 541 AA.
AC U5WQN7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=23S rRNA methyltransferase {ECO:0000313|EMBL:AGZ51484.1};
GN ORFNames=MKAN_15315 {ECO:0000313|EMBL:AGZ51484.1};
OS Mycobacterium kansasii ATCC 12478.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=557599 {ECO:0000313|EMBL:AGZ51484.1, ECO:0000313|Proteomes:UP000017786};
RN [1] {ECO:0000313|EMBL:AGZ51484.1, ECO:0000313|Proteomes:UP000017786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12478 {ECO:0000313|EMBL:AGZ51484.1,
RC ECO:0000313|Proteomes:UP000017786};
RG McGill University Mycobacterium genome consortium;
RA Veyrier F.J., Behr M.A.;
RT "Genome sequence of Mycobacterium kansasii.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
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DR EMBL; CP006835; AGZ51484.1; -; Genomic_DNA.
DR RefSeq; WP_023369207.1; NC_022663.1.
DR AlphaFoldDB; U5WQN7; -.
DR GeneID; 29702068; -.
DR KEGG; mkn:MKAN_15315; -.
DR eggNOG; COG1053; Bacteria.
DR HOGENOM; CLU_011398_4_4_11; -.
DR OrthoDB; 337830at2; -.
DR Proteomes; UP000017786; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0033765; F:steroid dehydrogenase activity, acting on the CH-CH group of donors; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0008202; P:steroid metabolic process; IEA:UniProt.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR InterPro; IPR003953; FAD-binding_2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR027477; Succ_DH/fumarate_Rdtase_cat_sf.
DR PANTHER; PTHR43400:SF7; FAD_BINDING_2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43400; FUMARATE REDUCTASE; 1.
DR Pfam; PF00890; FAD_binding_2; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF56425; Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain; 1.
PE 4: Predicted;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Methyltransferase {ECO:0000313|EMBL:AGZ51484.1};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transferase {ECO:0000313|EMBL:AGZ51484.1}.
FT DOMAIN 14..506
FT /note="FAD-dependent oxidoreductase 2 FAD binding"
FT /evidence="ECO:0000259|Pfam:PF00890"
SQ SEQUENCE 541 AA; 57083 MW; EE64B04C400F898D CRC64;
MAGDKSARIG ESADVVVIGF GAAGECAAIA ARERGADVIA LDRANGGGAT AISGGIIYAG
GGTKVQRQAG VNDSPEQMLA YLRLEVGDAV SQETLESFVR SSPEMIDWLS SYGVPFSPAL
CPYKTSFPNN HYYLYHSGSE NAGAFRCHTP PVQRGHRVQG RGTSGRKLYA PLAKAALALG
VRFWPHTTVT KLIQDSSGRV TGVDVLTMHF APPRIQRRYA AAAKLSAKPG IYYPPLRRLM
EGQLRRLERR YAQPVRIHAR RAVIICAGGF IANTEWVQRF APQYVGGLQL GTSGDDGTGI
ALAQSVGAVT DRMDNVSAWR FITPPSAFIG AVIVDRGGHR VIDESRYGAA VGQAMIQQHE
GAGWLLADAA LMREARRQMI KQPLWFQRAQ VAALMLADAV TAPSLPEVAK AAGIDPDGLV
ATVAAHNAAI DAGAPDPAGK PAEFVRRISQ APFTLLNISV RPSLLNPTPM LTLGGIRVDE
RSGAVVNESG DPIPGLFGAG RTAAGVCSNS YVSGLSLADC VFSGRRAGAH AAAAPAEQSS
R
//
