ID U5WSP6_MYCKA Unreviewed; 479 AA.
AC U5WSP6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Dehydrogenase {ECO:0000313|EMBL:AGZ52253.1};
GN ORFNames=MKAN_19610 {ECO:0000313|EMBL:AGZ52253.1};
OS Mycobacterium kansasii ATCC 12478.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=557599 {ECO:0000313|EMBL:AGZ52253.1, ECO:0000313|Proteomes:UP000017786};
RN [1] {ECO:0000313|EMBL:AGZ52253.1, ECO:0000313|Proteomes:UP000017786}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12478 {ECO:0000313|EMBL:AGZ52253.1,
RC ECO:0000313|Proteomes:UP000017786};
RG McGill University Mycobacterium genome consortium;
RA Veyrier F.J., Behr M.A.;
RT "Genome sequence of Mycobacterium kansasii.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
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DR EMBL; CP006835; AGZ52253.1; -; Genomic_DNA.
DR RefSeq; WP_023370912.1; NC_022663.1.
DR AlphaFoldDB; U5WSP6; -.
DR GeneID; 29700084; -.
DR KEGG; mkn:MKAN_19610; -.
DR eggNOG; COG2303; Bacteria.
DR HOGENOM; CLU_002865_7_1_11; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000017786; Chromosome.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023978; GMC_oxidoreductase_bact.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR NCBIfam; TIGR03970; Rv0697; 1.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 3.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630}.
FT DOMAIN 9..298
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 358..474
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT BINDING 224
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 452
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 479 AA; 50365 MW; 17EB02207049BC94 CRC64;
MTAATGHSDV LIVGAGSAGS VVAARLSSDP RCVVTVLEAG PGLADPELLA QTSDGLRLPI
GIGSPLVRRY QTQLTDRPIR RLAIVRGATL GGCGAINGGY FCRGLPQDFD RAALPGWAWS
DVLEHFRAIE TDLDFSTPAH GSTGPILIRR TREMTGITQR FITAAERAGF PWIDDLNDVG
PSTVPGVGAV PLNIVDGVRT GAGAGYLLPA LRRPNLTLLE QTRVLRLRFA GTRAVGVDAV
GPCGPTTLTA DRIVLCAGAI ESAHLLMLSG VGDEAMLRAV GVPVVAPLPV GMSCTDHPEW
VLPTTWGVAP ERPVLEVVLH TADDLEIRPY TGGFVAMTGN DTAGQPDWPH IGVALMRPRA
RGRITLISAD PDVPPRIEHR YDSEPADVAD LQQGAELAHE IAGGTTAVGQ PAWSTSQHLC
GSAAMGADGD PRGVVDVRCR VRGIQNLWVI DGSILPEITS RGPHATIVML GHRAAEFVA
//
