ID U5Y6W9_9BACT Unreviewed; 559 AA.
AC U5Y6W9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=Intimin {ECO:0000256|ARBA:ARBA00017346};
DE AltName: Full=Attaching and effacing protein {ECO:0000256|ARBA:ARBA00029955};
DE Flags: Fragment;
GN Name=eae {ECO:0000313|EMBL:AGZ84303.1};
OS uncultured bacterium.
OC Bacteria; environmental samples.
OX NCBI_TaxID=77133 {ECO:0000313|EMBL:AGZ84303.1};
RN [1] {ECO:0000313|EMBL:AGZ84303.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=24141131; DOI=10.1128/AEM.02747-13;
RA Yang K., Pagaling E., Yan T.;
RT "Estimating the Prevalence of Potential Enteropathogenic Escherichia coli
RT and Intimin Gene Diversity in a Human Community by Monitoring Sanitary
RT Sewage.";
RL Appl. Environ. Microbiol. 80:119-127(2014).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004203}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004203}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the intimin/invasin family.
CC {ECO:0000256|ARBA:ARBA00010116}.
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DR EMBL; KF771374; AGZ84303.1; -; Genomic_DNA.
DR AlphaFoldDB; U5Y6W9; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR Gene3D; 2.60.40.1080; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.40.160.160; Inverse autotransporter, beta-domain; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR InterPro; IPR003344; Big_1_dom.
DR InterPro; IPR003343; Big_2.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR024519; IAT_beta.
DR InterPro; IPR038177; IAT_beta_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003535; Intimin/invasin_bac.
DR InterPro; IPR013117; Intimin_C.
DR InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR PANTHER; PTHR39576:SF2; ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED; 1.
DR PANTHER; PTHR39576; ATTACHING AND EFFACING PROTEIN HOMOLOG-RELATED-RELATED; 1.
DR Pfam; PF02369; Big_1; 2.
DR Pfam; PF02368; Big_2; 1.
DR Pfam; PF11924; IAT_beta; 1.
DR Pfam; PF07979; Intimin_C; 1.
DR PRINTS; PR01369; INTIMIN.
DR SMART; SM00634; BID_1; 2.
DR SMART; SM00635; BID_2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 3.
DR PROSITE; PS51127; BIG1; 2.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 181..274
FT /note="Big-1"
FT /evidence="ECO:0000259|PROSITE:PS51127"
FT DOMAIN 281..372
FT /note="Big-1"
FT /evidence="ECO:0000259|PROSITE:PS51127"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGZ84303.1"
SQ SEQUENCE 559 AA; 60183 MW; 3E8CB7B5DAF37BDC CRC64;
TPIPLVTMGV DYRHGTGNEN DLLYSMQFRY QFDKPWSQQI EPQYVNELRT LSGSRYDLVQ
RNNNIILEYK KQDILSLSIP HDINGTEHST QKIQLSVKSK YGLDRIAWDD SALRSQGGQI
QHSGSQSVQD YQAILPAYVQ GGSNIYKVTA RAYDRNGNSS NNVQLTITVL SNGQVVDQVG
VTDFTADKTS ALADGTDTIT YTAVVKKNGV TQANVPVSFN IVSGTATLSA KSANTNSSGK
VTVTLKSDKP GQVVVSAKTA EMTSALNAHA VIFVDQTQAS ITEINADKKT AKANGSDAIT
YTVKVMKDGK PLSAQDVTFT ATLGTLSKST EKTDANGYAK VTLTSKTTGK SLVSASISGS
AIDVKAPEVE FFTPLAIDDG NVEIVGTGIK GTLPTVWLQY GQVKLKASGG DGKYTWSSAN
TGIASVDSTG QVTLRDKGST TITVVSGDKQ TATYIIARPS SMIVSINERM TYNNAMSSCQ
SLSGRLPSSQ KELADVFDTW GAANKYEHYE TRNTMISWTK QTDQDMSQGV ASTYDLIKKN
PLTNKVDINN PNAYATCVK
//
