ID U6CUI0_NEOVI Unreviewed; 3065 AA.
AC U6CUI0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Collagen alpha-1(XII) chain {ECO:0000313|EMBL:CCP74131.1};
GN Name=COCA1 {ECO:0000313|EMBL:CCP74131.1};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP74131.1};
RN [1] {ECO:0000313|EMBL:CCP74131.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pool of brain {ECO:0000313|EMBL:CCP74131.1};
RA Anistoroaei R., Christensen K.;
RT "An American mink transcriptome.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HAAF01002305; CCP74131.1; -; mRNA.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 18.
DR CDD; cd01482; vWA_collagen_alphaI-XII-like; 4.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 18.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 4.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF70; PH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01391; Collagen; 4.
DR Pfam; PF00041; fn3; 18.
DR Pfam; PF00092; VWA; 4.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00060; FN3; 18.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00327; VWA; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 12.
DR SUPFAM; SSF53300; vWA-like; 4.
DR PROSITE; PS50853; FN3; 17.
DR PROSITE; PS50234; VWFA; 4.
PE 2: Evidence at transcript level;
KW Collagen {ECO:0000256|ARBA:ARBA00023119, ECO:0000313|EMBL:CCP74131.1};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..3065
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004669137"
FT DOMAIN 27..117
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 140..316
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 336..426
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 440..616
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 634..723
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 725..813
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 816..905
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 907..998
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1000..1087
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1089..1179
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1199..1371
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1387..1476
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1477..1567
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1568..1657
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1658..1754
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1757..1851
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1938..2028
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2029..2119
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2120..2208
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2209..2296
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2325..2498
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 803..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1074..1099
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2013..2032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2285..2314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2752..2898
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2933..3065
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2299..2314
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2780..2799
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2826..2840
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2942..2956
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3020..3038
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3050..3065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3065 AA; 332986 MW; 9A2FA7A6BD7EE4DD CRC64;
MRTRLPPALA ALGAALLLSS IEAEVDPPSD LNFKIIDENT VHMSWARPAD PIVGYRITVD
PTTDGPTKEF TLAASTTETL LSDLIPEIEY VVTITSYDEV EESVPVIGQL TIQTGGPTKP
GEKKPGKPEI QKCSVSAWTD LVFLVDGSWS VGRNNFKYIL DFIGALVSAF DIGEEKTRVG
VVQYSSDTRT EFNLNQYYQR DELLAAIKRI PYKGGNTMTG DAIDYLIKNT FTESAGARVG
FPKVAIIITD GKSQDEVEIP ARELRNIGVE VFSLGIKAAD AKELKQIAST PSLNHVFNVA
NFDAIVDIQN EIISQVCSGV DEQLGELVSG EEVIEPPSNL VATEVSSKYI KLGWSPSPSP
VTGYKVLLTP MTAGSRQHAL SVGPQTTTLS VRDLSADTEY QISVSAMKGL TSSEPISIME
KTQPMKVQVE CSRGVDIKAD IVFLVDGSYS IGIANFVKVR AFLEVLVKSF EISPNRVQIS
LVQYSRDPHT EFTLKKFTRV EDIIEAINTF PYRGGSTNTG KAMTYVREKI FVPSKGSRGN
VPKVMILITD GKSSDAFRDP AIKLRNSDVE IFAVGVKDAV RSELEAIASP PAETHVFTVE
DFDAFQRISF ELTQSICLRI EQELAAIKKK AYVPPKDLSF SETTSHSFKT NWSPAGENVF
SYHITYKEAT GDDEVTVVEP ASSTSVILSN LKPETLYLVN VTAEYEDGFS VPLSGEETTV
EVKGAPRNLK VTDETTDSFK ITWTQAPGRV LRYRIMYKPV AGGESKEVTT PANQRRITLE
NLTPDTKYEV SVIPEYFSGP GSSLTGNAAT EEVRGNPRDL RVSDPTTSTM KLSWTGAPGK
VKQYLVTYVP AAGGETQEVT VRGHTTSTVL RGLNEGTQYS LSVTALYASG AGDTLHGEGT
TLEERGSPTD FVTKDITDTS IGAYWTSAPG MVRGYRVSWK SLYDDIETGE KSLPGDAIHT
VIENLQPETK YKVSVFAVYS SGEGEPLNGE ATTELSQDSK ILKVDEETEN TMRVTWKPAP
GKVINYRVVY RPRGGGRQMV AKVPPTVTST VLKRLQPQTT YDITVLPMYK TGEGKLRQGS
GTTASRFKSP RNLKTSDPTM SSFRVTWEPA PGEVKGYKVT FHPTGDDRRL GELVVGPYDN
TVVLEELRAG TTYKVNVFGM FDGGESSPLV GQEMTTLSDT TVMPILSSGM ECITRAEADI
VLLVDGSWSI GRANFRTVRS FISRIVEVFE IGPKRVQIAL AQYSGDPRTE WQLNAHRDKK
SLLQAVANLP YKGGNTLTGM ALNFIRQQSF RTQAGMRPRA RKIGVLITDG KSQDDVEAPS
KKLKDEGVEL FAVGIKNADE DELKMIATDP DDTHAYNVAD FESLSKIVDD LTINLCNSVK
GPGDLEAPSN LVISERTHRS LRVSWTPPSD SVDRYKVEYY PVSGGKRQEF YVSRLESSTV
LKDLKPETEY VVNVYSVVED EYSEPLKGTE KTLPVPVVSM NIYDVGPTTM HVQWQPVGGA
TSYTLSYEPI NATEPRKPKE MRVGPTVNDV QLTDLFPNTE YAVTVQAALH DLASEPVTAR
EVTLPLPKPR DLRLRDVTHS TMNVLWEPAP GKVRKYIVRY KTPEDDVKEV EVDRSRTSTP
LKDLFSQTLY TVGVSAVYDE GESPPMTAQE TTRTVPAPTN LRITDVTPES FRGTWDHGAS
DVSLYRITWA PFGSSDRMET ILNGDENTLV FENLNPNTLY EVSVTAIYPD ESESDDLTGS
ERTPRLIPLT TQAPKSGPRN LQVYNATSNS LTVKWDPASG RVQKYRITYQ PSTGEGNEQT
TTIGGRQNSV VLQKLKPDTP YTITVSSLYP DGEGGRMTGR GKTKPLNTVR NLRVYDPSTS
TLNVRWDHAE GNPRQYKLFY APTAGGPEEL VPIPGNTNYA ILRNLQPDTP YTVTVVPVYT
EGDGGRTSDT GRTLVRGLAR NVHVYNPTPN SLDVRWDPAP GPVQQYRVIY SPVAGTRPSE
SIVVPGNTRT VHLERLIPDT PYSVNIVALY SDGEGNPSPG QGRTLPRSGP RNMRVFGETT
NSLSVTWDHA DGPVQQYRII YSPTVGDPID EYTTVPGRRN NVMLQPLQPD TPYKITVIAV
YEDGDGGHLT GNGRTMGLLP PQNIHISDEW YTRFRVSWDP SPSPVLGYKI VYKPVGSNEP
MEAFVGEMTS YTLHNLNPST TYDVDVYAQY DSGLSVPLTD QGTTLYLNVT DLKTYQVGWD
TFCVRWSPHR AATSYRLKLS PADGTRGQEI TVRGSETSHC FTGLSPDADY GVTVFVQTPN
LEGPGVSVKE HTTVKPTEAP TEPPTPPPPP TIPPARDVCK GAKADIVFLT DASWSIGDDN
FNKVVKFIFN TVGAFDEISP AGIQVSFVQY SDEVKSEFKL NTYNDKAQAL GALQNIRYRG
GNTRTGKALT FIKEKVLTWE SGMRKNVPKV LVVVTDGRSQ DEVKKAALVI QQSGFSVFVV
GVADVDYNEL ANIASKPSER HVFIVDDFES FEKIEDNLIT FVCETATSSC PLIYLDGYTS
PGFKMLEAYN LTEKNFASVP GVSLESGSFP SYSAYKLQKN AFVNQPTADL HPNGLPSSYT
IILLFRLLPE TPSDPFAIWQ ITDRDYKPQV GVIADPSSKT LSFFNKDTRG EVQTVTFDTD
EVKTLFYGSF HKVHIVVTSK SVKIYIDCYE IIEKDIKEAG NITTDGYEIL GKLLKGERKS
ATFQIQNFDI VCSPVWTSRD RCCDIPSRRD EAKCPALPNA CTCTQDSVGP PGPPGPAGGP
GAKGPRGERG ISGAVGPPGP RGDTGPPGPQ GPPGPQGPNG LSIPGEQGRQ GMKGDAGEPG
LPGRTGTPGL PGPPGPMGPP GDRGFTGKDG AMGPRGPPGP PGSPGSPGVT GPSGKPGKPG
DHGRPGPSGL KGEKGDRGDI ASQNMMRAVA RQVCEQLISG QMSRFNQMLN QIPNDYHSSR
NQPGPPGPPG PPGNAGARGE PGPGGRPGFP GTPGMQGPPG ERGLPGEKGE RGIGSPGPRG
LPGPPGPQGE SRTGPPGSTG SRGPPGPPGR PGNSGIRGPP GPPGYCDSSQ CASIPYNGQG
YPGSG
//
