ID U6CWI6_NEOVI Unreviewed; 495 AA.
AC U6CWI6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Sorting nexin-8 {ECO:0000313|EMBL:CCP74821.1};
GN Name=SNX8 {ECO:0000313|EMBL:CCP74821.1};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP74821.1};
RN [1] {ECO:0000313|EMBL:CCP74821.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pool of brain {ECO:0000313|EMBL:CCP74821.1};
RA Anistoroaei R., Christensen K.;
RT "An American mink transcriptome.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; HAAF01002995; CCP74821.1; -; mRNA.
DR AlphaFoldDB; U6CWI6; -.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR46571; SORTING NEXIN-8; 1.
DR PANTHER; PTHR46571:SF1; SORTING NEXIN-8; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 104..212
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 495 AA; 56791 MW; 7ABAEA57B10826A3 CRC64;
MWRLGEQIQP REEERITSLF TELWKCLAVT GVFELSFGED SIPKFSAKKY PRTWKDLKRL
FIFTLLQDSP TPQVSQRRDP HPSRMQMPQG NPLLLSCTLQ ELLARDTVQV ELIPGKKGLF
LKHVEYEVSS QRFKSSVYRR YNDFVVFHEM LLQKFPYRMV PALPPKRVLG ADREFIEARR
RALRRFINLV ARHPPFSEDV ALRLFLSFSG PDVQNKLKES AQCVGDEFMN CKLAPRAKDF
LPADIQTQFA VSRELIRNIY NSFHKLRDRA ERIASRAIDN AADLLIFGKE LSALGSDTTP
LPSWASLNSS TWGSLKQALK GLSVEFALLA DKAAQQGKQE ENDVVEKLNL FLDLLQSYKD
LCERHEKGVL HKHQRALHKY SLMKRQMLSA AVQSREPESV EQLESRIVEQ ENAIQTMELR
SYFSLYCLHQ ETQLVHAYLP LTSHILGAFV NSQIQGHKEM SKVWNDLQPK LSCLFAGPSS
SLLPPGPLQD GRSSH
//
