ID U6D0E8_NEOVI Unreviewed; 551 AA.
AC U6D0E8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Polycystic kidney disease 1 (Autosomal dominant) {ECO:0000313|EMBL:CCP76405.1};
DE Flags: Fragment;
GN Name=E7ES18 {ECO:0000313|EMBL:CCP76405.1};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP76405.1};
RN [1] {ECO:0000313|EMBL:CCP76405.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pool of brain {ECO:0000313|EMBL:CCP76405.1};
RA Anistoroaei R., Christensen K.;
RT "An American mink transcriptome.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; HAAF01004580; CCP76405.1; -; mRNA.
DR AlphaFoldDB; U6D0E8; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR PANTHER; PTHR46730:SF3; POLYCYSTIN-1; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
PE 2: Evidence at transcript level;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 394..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 231..346
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CCP76405.1"
FT NON_TER 551
FT /evidence="ECO:0000313|EMBL:CCP76405.1"
SQ SEQUENCE 551 AA; 60700 MW; 99B08C6B7236C47B CRC64;
QGPRAPAGSA VVPPRASVGV VVTPEESNPA AGLHLQLTYT LLSEHYLPEE PEPYLAVYLH
SASWPNEHNC SASRRIRLEQ LAGDDHRPYT FFIAPGTRDP GGTYHLNLTS HFHWSALEVT
VGLYTSLCQY FSEKEMMWRT EGLVPLEETS PSQAVCLTRH LTAFGASLFV PPSRVHFIFP
EPASGMNYVV LLTCSVCLVT YAVMAVVLRK LDQLDVRRVR VIPFCGKGGR FKYEILVKTG
WGRGSGTTAH VGIMLYGAEG RSGHRPLDGD RAFRRNSLDV FQIATPHSLG RVCKIRVWHD
NKGLSPAWFL QHVIVRDLQT ARSTFFLVNE WLSVETEANG GLVEKEVPAA SEAALRQSRR
LLVAELQRGF FDKHIWLSVW DRPPRSRFTR VQRATCCILL VCLFLGANAV WYGVVGDAAH
SAGPVSTRIP LSADTVAVGL VSSVVVYPVY LVILFLFRMS RSKVAGGESP TPAGQPVLDI
DSYLDPSVLD SSLLSFSGLR VEAFVGQMKS DFSDDSKSLT CWPSSEDTLH WPDLLSDPSI
VGSTLQRLGP G
//
