ID   U6D1K9_NEOVI            Unreviewed;       507 AA.
AC   U6D1K9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Bifunctional polynucleotide phosphatase/kinase {ECO:0000313|EMBL:CCP76424.1};
DE   Flags: Fragment;
GN   Name=PNKP {ECO:0000313|EMBL:CCP76424.1};
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Neogale.
OX   NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP76424.1};
RN   [1] {ECO:0000313|EMBL:CCP76424.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pool of brain {ECO:0000313|EMBL:CCP76424.1};
RA   Anistoroaei R., Christensen K.;
RT   "An American mink transcriptome.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HAAF01004599; CCP76424.1; -; mRNA.
DR   AlphaFoldDB; U6D1K9; -.
DR   GO; GO:0046404; F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; IEA:InterPro.
DR   GO; GO:0046403; F:polynucleotide 3'-phosphatase activity; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01625; HAD_PNP; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR041388; FHA_2.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006549; HAD-SF_hydro_IIIA.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013954; PNK3P.
DR   InterPro; IPR006550; PNKP.
DR   InterPro; IPR006551; Polynucleotide_phosphatase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   NCBIfam; TIGR01664; DNA-3'-Pase; 1.
DR   NCBIfam; TIGR01662; HAD-SF-IIIA; 1.
DR   NCBIfam; TIGR01663; PNK-3'Pase; 1.
DR   PANTHER; PTHR12083; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE; 1.
DR   PANTHER; PTHR12083:SF9; BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF17913; FHA_2; 1.
DR   Pfam; PF08645; PNK3P; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Kinase {ECO:0000313|EMBL:CCP76424.1};
KW   Transferase {ECO:0000313|EMBL:CCP76424.1}.
FT   DOMAIN          5..65
FT                   /note="PNK FHA"
FT                   /evidence="ECO:0000259|Pfam:PF17913"
FT   REGION          96..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CCP76424.1"
SQ   SEQUENCE   507 AA;  55832 MW;  FBF6C28B3B1CDD80 CRC64;
     PPGGAPPIFL PSDRQVLVLG RGPLTQVTDR KCSRNQVELV ADPGTKTVAV KQLGINPSTA
     GTQELAPGSE GSLRLGDTLY LVNGLHPLTL RWEEARTPES QQDTPPCTPP VAPDVAQDVE
     PQKKRMRKSS PGWEKFEKLL VFTAPGAKPR GKVAGFDLDG TLITTRSGKV FPTGPSDWRI
     LYLEIPQKLR ELDAEGYKLV IFTNQMAIGR GKLPAEEFKA KVEAVVEKLG LPFQVLVATH
     AGLYRKPVVG MWDHLQEQAN EDMPISIRDS VFVGDAAGRP ANWAPGRKKK DFSCADRLFA
     LNLGLPFATP EEFFLKWPIA SFVLPTFDPR TVSPSGPLYL PESSSLLSSD PEVVVAVGFP
     GAGKSTFLQE HLVSAGYVHV NRDTLGSWQR CVTMCENALK QRKRVVIDNT NPDPPSRARY
     IKCAQDAGVP CRCFLFTATL EQARHNNRFR EMTGSSHAPV SDVVMYGYRK QFEAPTLAEG
     FSAILDIPFR LNVEPTLRRL YTQFSEG
//