ID U6D3D5_NEOVI Unreviewed; 668 AA.
AC U6D3D5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Protein phosphatase 1 regulatory subunit 12C {ECO:0000313|EMBL:CCP76378.1};
DE Flags: Fragment;
GN Name=PP12C {ECO:0000313|EMBL:CCP76378.1};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP76378.1};
RN [1] {ECO:0000313|EMBL:CCP76378.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pool of brain {ECO:0000313|EMBL:CCP76378.1};
RA Anistoroaei R., Christensen K.;
RT "An American mink transcriptome.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber
CC {ECO:0000256|ARBA:ARBA00004529}.
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DR EMBL; HAAF01004553; CCP76378.1; -; mRNA.
DR AlphaFoldDB; U6D3D5; -.
DR GO; GO:0001725; C:stress fiber; IEA:UniProtKB-SubCell.
DR GO; GO:0019208; F:phosphatase regulator activity; IEA:InterPro.
DR GO; GO:0019901; F:protein kinase binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd21945; IPD_PPP1R12C; 1.
DR Gene3D; 6.10.140.390; -; 1.
DR Gene3D; 6.10.250.1820; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR017401; MYPT1/MYPT2/Mbs85.
DR InterPro; IPR031775; PRKG1_interact.
DR PANTHER; PTHR24179; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12; 1.
DR PANTHER; PTHR24179:SF27; PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 12C; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF15898; PRKG1_interact; 1.
DR PIRSF; PIRSF038141; PP1_12ABC_vert; 4.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}.
FT REPEAT 10..42
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 43..75
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 136..168
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 169..201
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 569..668
FT /note="cGMP-dependent protein kinase interacting"
FT /evidence="ECO:0000259|Pfam:PF15898"
FT REGION 226..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..322
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..442
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..573
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CCP76378.1"
SQ SEQUENCE 668 AA; 72803 MW; 5825B6E0ECE7F475 CRC64;
RAVLDSTNAD GISALHQACI DENLEVVRFL VEQGATVNQA DNEGWTPLHV AASCGYLDIA
RYLLSHGANI AAVNSDGDLP LDLAESDAME GLLKAEIAFR GVDVEAAKRA EEELLLHDTR
CWLNGGAMPE ARHPRTGASA LHVAAAKGYI EVMRLLLQAG YDPELRDGDG WTPLHAAAHW
GVEDACRLLA EHGGGMDSLT HAGQRPCDLA DEEVLSLLEE LARKQEDLRN QKEASQSRSQ
EPQGPSSSKH RRSSVCRLSS REKISLQDLS KERRPGGAGG PPIQDEDEGE EGLTGPPSPE
SRALNGVSSP PPPGPQGPMP PEEAPFSRRF GLQKTGSSGT LGPTDRQGAE GTPGAALQRS
ASSSRLEGSS AQAKEPRLAR IMPTPSRKLL EPSALISEPE SPVKPSVPVA STVLPADSRD
RRRSYQMPVR DEESESQRKA RSRLMRQSRR STQGVTLTDL KEAEKVAGKA PEPEKLCLQS
LDPSRRPRVP GVENSDGPAP RAEAPDGQGQ GPQATKEHRR VGKEWRGLAE GEEAEPADRS
PDSSTSEGGP SPRRQRDPEP ALEEPDGGFR KLYSELRSEN ERLREALTET TLRLAQLKVE
LERATQRQER FAERPALLEL ERFERRALER KAAELEEELK ALSDLRADNQ RLKDENAALI
RVISKLSK
//
