ID U6DA64_NEOVI Unreviewed; 492 AA.
AC U6DA64;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=Vav 2 guanine nucleotide exchange factor {ECO:0000313|EMBL:CCP78793.1};
DE Flags: Fragment;
GN Name=F8WEQ4 {ECO:0000313|EMBL:CCP78793.1};
OS Neovison vison (American mink) (Mustela vison).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Neogale.
OX NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP78793.1};
RN [1] {ECO:0000313|EMBL:CCP78793.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Pool of brain {ECO:0000313|EMBL:CCP78793.1};
RA Anistoroaei R., Christensen K.;
RT "An American mink transcriptome.";
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HAAF01006969; CCP78793.1; -; mRNA.
DR AlphaFoldDB; U6DA64; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01223; PH_Vav; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022613; CAMSAP-like_CH_dom.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR037832; PH_Vav.
DR PANTHER; PTHR45818:SF4; GUANINE NUCLEOTIDE EXCHANGE FACTOR VAV2; 1.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR Pfam; PF11971; CAMSAP_CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
FT DOMAIN 1..114
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 187..365
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 394..492
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CCP78793.1"
FT NON_TER 492
FT /evidence="ECO:0000313|EMBL:CCP78793.1"
SQ SEQUENCE 492 AA; 57610 MW; 4A2A7536A4B16D59 CRC64;
CGRWLIDCKV LPPNHRVVWP SAVVFDLAQA LRDGVLLCQL LHNLSPGSID LKDINFRPQM
SQFLCLKNIR TFLKVCHDKF GLRNSELFDP FDLFDVRDFG KVISAVSRLS LHHVAQNKGI
RPFPSEETAE NDDDVYRSLE ELADEHDLGE DIYDCVPCED EGDDIYEDII KVEVRQPMKM
GMSEDDKRNC CLLEIQETEA KYYRTLEDIE KNYMTPLRQV LSPADVTAIF INLEDLIKVH
HSFLRAIDVS MMAGGSTLAK VFLDFKERLL IYGDYCSHME HAQNTLNQLL AGREDVRQKV
EECTLKVQDG KFKLQDLLVV PMQRVLKYHL LLKELLSHST DRPERQQLKE ALEAMQDLAM
YINEVKRDKE TLKKISEFQS SIENLQVKLE EYGRPKIDGE LKVRSIVNHT KQDRYLFLFD
KVVIVCKRRG YSYELKEVIE LLFHKMTDDP MNNKDVKKWS YGFYLIHLQG KQGFQFFCKT
EDMKRKWMEQ FE
//
