ID   U6DMU4_NEOVI            Unreviewed;       606 AA.
AC   U6DMU4;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Probable E3 ubiquitin-protein ligase HERC6 {ECO:0000313|EMBL:CCP83228.1};
DE   Flags: Fragment;
GN   Name=HERC6 {ECO:0000313|EMBL:CCP83228.1};
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Neogale.
OX   NCBI_TaxID=452646 {ECO:0000313|EMBL:CCP83228.1};
RN   [1] {ECO:0000313|EMBL:CCP83228.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pool of brain {ECO:0000313|EMBL:CCP83228.1};
RA   Anistoroaei R., Christensen K.;
RT   "An American mink transcriptome.";
RL   Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HAAF01011404; CCP83228.1; -; mRNA.
DR   AlphaFoldDB; U6DMU4; -.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   2: Evidence at transcript level;
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          276..600
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        568
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:CCP83228.1"
SQ   SEQUENCE   606 AA;  70575 MW;  545B2D88B95B1432 CRC64;
     IFSSPACLTA SFLKKRESVE TISIDVDLQK ARDTFEKLTK TEWISLMITT CLRDNLLRAL
     PCCSSHQEAL LVFLLLLECP VMHDSRNWWS LVVPFAKAVC KIRKSQVLKQ CLASLQESSF
     NKMIQMLKTA IISQLYQWTE TSQSYCSLKA FLGMMKEVHK VNTANCRLPE NTFIIDEFPS
     AVIFHESTRR LFFRDNNLIP AENLSPIIFS DFPFIFNLPC KIQLLRAESH LKMLDLKQRE
     YLDQGQGILQ FNQPLPFKVR RSHLVEDALR QLNQVEDTNL CKGLVIEFTK EIRSPGYGVI
     AEFFYYIFEE MTKTEYGMFI YPEEGSYMWF PVSPVFEKKR YFLFGILCGL SLNNSNVANL
     PFPLALFKKL LGQKPSLQDL KELSPLLGKN LQVLNNEADD IGKELYIYFS IHWDKKDVDL
     IPNGISVPVD QSNKKEYVSA CIDYIFDISV EAVYEEFQRG FYKVCDKEIL VKLFQPEELM
     AAVVGNTDYD WKQFEENSQY DQEYHKSHPT ILMFWKAFHK LTLEEKRKFL FFLRGNDRLP
     LRGKQQMGIT FRCPETFRET DYPRALTCHN ILDFPKYSTM EKVEEALQVA INSNRGFASV
     QVTEQQ
//