GenomeNet

Database: UniProt
Entry: U6EEP1_9EURY
LinkDB: U6EEP1_9EURY
Original site: U6EEP1_9EURY 
ID   U6EEP1_9EURY            Unreviewed;       550 AA.
AC   U6EEP1;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 20.
DE   RecName: Full=Methyl-coenzyme M reductase subunit alpha {ECO:0000256|PIRNR:PIRNR000262};
DE            EC=2.8.4.1 {ECO:0000256|PIRNR:PIRNR000262};
GN   Name=mcrA {ECO:0000313|EMBL:CDG65773.1};
GN   ORFNames=MBMB1_1682 {ECO:0000313|EMBL:CDG65773.1};
OS   Methanobacterium sp. MB1.
OC   Archaea; Euryarchaeota; Methanobacteria; Methanobacteriales;
OC   Methanobacteriaceae; Methanobacterium.
OX   NCBI_TaxID=1379702 {ECO:0000313|EMBL:CDG65773.1, ECO:0000313|Proteomes:UP000017867};
RN   [1] {ECO:0000313|EMBL:CDG65773.1, ECO:0000313|Proteomes:UP000017867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MB1 {ECO:0000313|Proteomes:UP000017867};
RA   Maus I., Wibberg D., Stantscheff R., Cibis K., Eikmeyer F.G.,
RA   Puehler A., Koenig H., Schlueter A.;
RT   "Methanobacterium sp. Mb1.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Reduction of methyl-coenzyme M (2-(methylthio)
CC       ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate
CC       to methane and a heterodisulfide. {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- CATALYTIC ACTIVITY: Methyl-CoM + CoB = CoM-S-S-CoB + methane.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- COFACTOR:
CC       Name=coenzyme F430; Xref=ChEBI:CHEBI:60540;
CC         Evidence={ECO:0000256|PIRNR:PIRNR000262};
CC       Note=Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme
CC       F430 is a yellow nickel porphinoid.
CC       {ECO:0000256|PIRNR:PIRNR000262};
CC   -!- PATHWAY: One-carbon metabolism; methyl-coenzyme M reduction;
CC       methane from methyl-coenzyme M: step 1/1.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -!- SUBUNIT: Hexamer of two alpha, two beta, and two gamma chains.
CC       {ECO:0000256|PIRNR:PIRNR000262}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; HG425166; CDG65773.1; -; Genomic_DNA.
DR   RefSeq; WP_023992801.1; NC_023044.1.
DR   EnsemblBacteria; CDG65773; CDG65773; MBMB1_1682.
DR   GeneID; 23801512; -.
DR   KEGG; meth:MBMB1_1682; -.
DR   PATRIC; fig|1379702.4.peg.1673; -.
DR   KO; K00399; -.
DR   OrthoDB; POG093Z00ZI; -.
DR   UniPathway; UPA00646; UER00699.
DR   Proteomes; UP000017867; Chromosome.
DR   GO; GO:0050524; F:coenzyme-B sulfoethylthiotransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.840.10; -; 1.
DR   Gene3D; 3.30.70.470; -; 1.
DR   Gene3D; 3.90.390.10; -; 1.
DR   InterPro; IPR016212; Me_CoM_Rdtase_asu.
DR   InterPro; IPR008924; Me_CoM_Rdtase_asu/bsu_C.
DR   InterPro; IPR009047; Me_CoM_Rdtase_asu_C.
DR   InterPro; IPR003183; Me_CoM_Rdtase_asu_N.
DR   InterPro; IPR015811; Me_CoM_Rdtase_asu_N_sub1.
DR   InterPro; IPR015823; Me_CoM_Rdtase_asu_N_sub2.
DR   InterPro; IPR009024; Me_CoM_Rdtase_Fd-like_fold.
DR   Pfam; PF02249; MCR_alpha; 1.
DR   Pfam; PF02745; MCR_alpha_N; 1.
DR   PIRSF; PIRSF000262; MCR_alpha; 1.
DR   SUPFAM; SSF48081; SSF48081; 1.
DR   SUPFAM; SSF55088; SSF55088; 1.
DR   TIGRFAMs; TIGR03256; met_CoM_red_alp; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000017867};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000256|PIRSR:PIRSR000262-1};
KW   Methanogenesis {ECO:0000256|PIRNR:PIRNR000262};
KW   Nickel {ECO:0000256|PIRNR:PIRNR000262, ECO:0000256|PIRSR:PIRSR000262-
KW   1}; Reference proteome {ECO:0000313|Proteomes:UP000017867};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000262,
KW   ECO:0000313|EMBL:CDG65773.1}.
FT   DOMAIN        3    268       MCR_alpha_N. {ECO:0000259|Pfam:PF02745}.
FT   DOMAIN      316    441       MCR_alpha. {ECO:0000259|Pfam:PF02249}.
FT   METAL       147    147       Nickel. {ECO:0000256|PIRSR:PIRSR000262-
FT                                1}.
FT   MOD_RES     257    257       Pros-methylhistidine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
FT   MOD_RES     271    271       5-methylarginine. {ECO:0000256|PIRSR:
FT                                PIRSR000262-2}.
SQ   SEQUENCE   550 AA;  60594 MW;  DB152C2A0049608E CRC64;
     MAEKMFINAL KKAFEEDPSD KTTTFYKFGG WRQSERKREF VEAGKEVAAK RGIPQYDPDV
     GTPLGQRVLM PYQVSTTDTF VEGDDLHFVN NAAMQQFWDD IRRTVIVGLN TAHSVIEKRL
     GKEVTPETIT HYLETVNHAM PGAAVVQEHM VETHPLLTAD SYVKVFTGND EIADEIDQRY
     VLDINEEFPE HQAEVLKAEV GDGMWTVVRI PTIVSRTCDG GTTSRWSAMQ VGMSMISAYK
     QAAGEAATGD FAYAAKHAEV IHMGTYLPVR RARGENEPGG IAFGYLADIC QSSRVHWEDP
     VRVSLDVVAS GAMLYDQIWL GSYMSGGVGF TQYATAAYTD NILDDFTYFG KEYVEDKYGI
     TEAPNTMDTV LDVGSEVTFY ALEQFEDYPA LLETIFGGSQ RASIVAAAAG CSTAFATGNA
     QTGLSAWYLS MYLHKEQHSR LGFYGYDLQD QCGASNVFSI RGDEGLPTEL RGANYPNYAM
     NVGHQGEYAG IAQAAHAARG DAFVLNPLVK IAFADPNLTF DFTQVRSEFA KGALREFEPA
     GERALISPAK
//
DBGET integrated database retrieval system