GenomeNet

Database: UniProt
Entry: U6EES5_9EURY
LinkDB: U6EES5_9EURY
Original site: U6EES5_9EURY 
ID   U6EES5_9EURY            Unreviewed;       530 AA.
AC   U6EES5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   SubName: Full=Acetolactate synthase {ECO:0000313|EMBL:CDG65569.1};
DE            EC=2.2.1.6 {ECO:0000313|EMBL:CDG65569.1};
GN   ORFNames=MBMB1_1471 {ECO:0000313|EMBL:CDG65569.1};
OS   Methanobacterium sp. MB1.
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanobacterium.
OX   NCBI_TaxID=1379702 {ECO:0000313|EMBL:CDG65569.1, ECO:0000313|Proteomes:UP000017867};
RN   [1] {ECO:0000313|EMBL:CDG65569.1, ECO:0000313|Proteomes:UP000017867}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MB1 {ECO:0000313|Proteomes:UP000017867};
RA   Maus I., Wibberg D., Stantscheff R., Cibis K., Eikmeyer F.G., Puehler A.,
RA   Koenig H., Schlueter A.;
RT   "Methanobacterium sp. Mb1.";
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HG425166; CDG65569.1; -; Genomic_DNA.
DR   AlphaFoldDB; U6EES5; -.
DR   STRING; 1379702.MBMB1_1471; -.
DR   KEGG; meth:MBMB1_1471; -.
DR   PATRIC; fig|1379702.4.peg.1466; -.
DR   HOGENOM; CLU_013748_3_1_2; -.
DR   BioCyc; MSP1379702:MBMB1_RS07130-MONOMER; -.
DR   Proteomes; UP000017867; Chromosome.
DR   GO; GO:0003984; F:acetolactate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006082; P:organic acid metabolic process; IEA:UniProt.
DR   GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR   GO; GO:0044272; P:sulfur compound biosynthetic process; IEA:UniProt.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR000399; TPP-bd_CS.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR18968:SF169; ACETOLACTATE SYNTHASE CATALYTIC SUBUNIT, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   PROSITE; PS00187; TPP_ENZYMES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000017867};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132};
KW   Transferase {ECO:0000313|EMBL:CDG65569.1}.
FT   DOMAIN          7..118
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          192..317
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          372..518
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   530 AA;  58128 MW;  8952B55514E99B6A CRC64;
     MEALEITLAD ALVKILENEH LEFIFGYPGE QILPFYQALQ KSNIRHILTR HEQGAVHAAD
     GYARASHHMG VCVATAGPGA LNMVMGVATA YKDSIPMLVI TGDVPLQLKG ENVFQDVDLN
     LVFAHITLQS HLVTDPERGI FITKKAISDL KTGKTGPIHL NFPKDVLQMK VDSIILENEV
     ETSPNTDWGG IDRIKMMVER SYKPLILAGA GVIWSHATTY LQEFAEKNQI PVATTYPARG
     ILSEEHPLSL GLIGLRGTEA ANFAGKNSDL ILALGCRLSE RTRKGLGSGT LIQVNLDKGV
     LDGDVNIKGD VKEFLDKIKE SNLNNTEQWL KEIQSLRKIH QVETNFKETP IRPQRAIKEI
     LDAMGDSILV NDAGSHTTWV NLIFKAREPS SLLFSGGFGP MGYGVPAAIG VSLAHPSRSV
     VVVVGDGGLQ MNIQELATIA ELDLPITICL LNNQSLGIIR QWQDLYYSGS FQVELENPDF
     VQLAEAYHIK ALRVDSPGDV FEAVQKAVKL NKPVFIEIEI NENEDIPLPG
//
DBGET integrated database retrieval system