ID U6EF71_9EURY Unreviewed; 634 AA.
AC U6EF71;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN Name=acsA3 {ECO:0000313|EMBL:CDG66118.1};
GN ORFNames=MBMB1_2044 {ECO:0000313|EMBL:CDG66118.1};
OS Methanobacterium sp. MB1.
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanobacterium.
OX NCBI_TaxID=1379702 {ECO:0000313|EMBL:CDG66118.1, ECO:0000313|Proteomes:UP000017867};
RN [1] {ECO:0000313|EMBL:CDG66118.1, ECO:0000313|Proteomes:UP000017867}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MB1 {ECO:0000313|Proteomes:UP000017867};
RA Maus I., Wibberg D., Stantscheff R., Cibis K., Eikmeyer F.G., Puehler A.,
RA Koenig H., Schlueter A.;
RT "Methanobacterium sp. Mb1.";
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HG425166; CDG66118.1; -; Genomic_DNA.
DR AlphaFoldDB; U6EF71; -.
DR STRING; 1379702.MBMB1_2044; -.
DR KEGG; meth:MBMB1_2044; -.
DR PATRIC; fig|1379702.4.peg.2023; -.
DR HOGENOM; CLU_000022_3_6_2; -.
DR BioCyc; MSP1379702:MBMB1_RS09945-MONOMER; -.
DR Proteomes; UP000017867; Chromosome.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR CDD; cd05966; ACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR011904; Ac_CoA_lig.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:CDG66118.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017867}.
FT DOMAIN 38..83
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 93..471
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 533..611
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 634 AA; 71438 MW; C60AB39D57200E2F CRC64;
MVESSNNAGN EKKVYKPNYM LVEEAHVKNW EAEIEKGKDI EKYWAEKAEQ FEWFKKWDQI
LDESNKPFYK WFVGGKINLA YNAVDRWIHT DKRNQVAILY ANERGDEKKL TYYELYREVN
KMANALKNLG VEKGDRVSMY MPMCPELLVS MLACNKIGAV HSVVYSGLSV GAFVERMNDA
KAKVLITADG TFRRGKIIDL KKIVDEALLK CHTIETTIVV KHAGNPIHMS ELSGKEIFYD
TLLKGEPDEC PVEEMDSEDP LFILYTSGST GKPKAVLHTT AGYMVGVATT LKTIFDIHNG
DLWWCTGDVG WITGHSYLVY GPLLLGTTTL VYEGAPDYPD PGIWWKIVEK YGVTKLYTSP
TAIRHLMRYG NKYPTIYNLS SLKILGSVGE PMNPAAWMWL YKNIGQERTP IMDTWWQTET
GMHMISPLPV SHLKPGTPTL PFPGVDIDVV DENGNPVPVG EDGYLVVKKP WPAMFRTLYN
DDERFVDAYW KEIPGGVYMA GDMARKDEDG YIWIQGRSDD VLKIAGHRVG TSEVEAAFSS
HPAVAEAAVI GKSDPVKGQV IKAFVILKEG YNLTTKLISE LQRHVRYELG PVAVLGDIVQ
VDKLPKTRSG KIMRRVLRAQ EEGKDLGDLS TLEE
//
