ID U6F8J3_LACHE Unreviewed; 279 AA.
AC U6F8J3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=nicotinate-nucleotide diphosphorylase (carboxylating) {ECO:0000256|ARBA:ARBA00011944};
DE EC=2.4.2.19 {ECO:0000256|ARBA:ARBA00011944};
DE AltName: Full=Quinolinate phosphoribosyltransferase [decarboxylating] {ECO:0000256|ARBA:ARBA00033102};
GN ORFNames=LHCIRMBIA951_00746 {ECO:0000313|EMBL:CDI59334.1};
OS Lactobacillus helveticus CIRM-BIA 951.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=1226334 {ECO:0000313|EMBL:CDI59334.1, ECO:0000313|Proteomes:UP000017248};
RN [1] {ECO:0000313|EMBL:CDI59334.1, ECO:0000313|Proteomes:UP000017248}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIRM-BIA 951 {ECO:0000313|EMBL:CDI59334.1,
RC ECO:0000313|Proteomes:UP000017248};
RA Valence F., Chuat V., Ma L., Creno S., Falentin H., Lortal S., Bizet C.,
RA Clermont D., Loux V., Bouchier C., Cousin S.;
RT "Draft Genome Sequence of five Lactobacillus helveticus strains CIRM-BIA
RT 101T, 103, 104, 951 and 953 isolated from milk product.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the catabolism of quinolinic acid (QA).
CC {ECO:0000256|ARBA:ARBA00003237}.
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-
CC ribonucleotide from quinolinate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004893}.
CC -!- SIMILARITY: Belongs to the NadC/ModD family.
CC {ECO:0000256|ARBA:ARBA00009400, ECO:0000256|PIRNR:PIRNR006250}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CDI59334.1}.
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DR EMBL; CBUK010000174; CDI59334.1; -; Genomic_DNA.
DR RefSeq; WP_023191347.1; NZ_HG530914.1.
DR AlphaFoldDB; U6F8J3; -.
DR STRING; 1587.ALV80_10255; -.
DR HOGENOM; CLU_039622_0_1_9; -.
DR UniPathway; UPA00253; UER00331.
DR Proteomes; UP000017248; Unassembled WGS sequence.
DR GO; GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01572; QPRTase; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1170.20; Quinolinate phosphoribosyl transferase, N-terminal domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR004393; NadC.
DR InterPro; IPR027277; NadC/ModD.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR InterPro; IPR037128; Quinolinate_PRibosylTase_N_sf.
DR InterPro; IPR002638; Quinolinate_PRibosylTrfase_C.
DR InterPro; IPR022412; Quinolinate_PRibosylTrfase_N.
DR NCBIfam; TIGR00078; nadC; 1.
DR PANTHER; PTHR32179; NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]; 1.
DR PANTHER; PTHR32179:SF3; NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]; 1.
DR Pfam; PF01729; QRPTase_C; 1.
DR Pfam; PF02749; QRPTase_N; 1.
DR PIRSF; PIRSF006250; NadC_ModD; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
DR SUPFAM; SSF54675; Nicotinate/Quinolinate PRTase N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|PIRNR:PIRNR006250};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000017248};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR006250}.
FT DOMAIN 19..105
FT /note="Quinolinate phosphoribosyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02749"
FT DOMAIN 107..270
FT /note="Quinolinate phosphoribosyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01729"
SQ SEQUENCE 279 AA; 29585 MW; 8B4E1BFACB959B06 CRC64;
MNPIVLKEKI SEFLKEDLGF GDLSVAFLPG GTPLSGSFIA KQSGIICGQE IPQATYDLLG
HATYKPRISD GAPVKAGDII GTVSGTAQTL LSGERVILNL IQRMSGIATQ TTHFVKLLDD
ATIRITDTRK TAPGLRLFDK YAVSVGGGFN HRFDLTGGIM LKDNHIALAG GVTQALAAVK
RHVGPLNPVE VEVETEEELR QAVAGGANII MFDNQNPETI KQWRQLVPKT IKVEASGGIT
AESISTFKGC GADFISIGNL TNDVTPLDIS FLVAGAVKS
//
