ID U6GDV2_EIMAC Unreviewed; 707 AA.
AC U6GDV2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Double-strand break repair protein, putative {ECO:0000313|EMBL:CDI78446.1};
GN ORFNames=EAH_00033690 {ECO:0000313|EMBL:CDI78446.1};
OS Eimeria acervulina (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5801 {ECO:0000313|EMBL:CDI78446.1};
RN [1] {ECO:0000313|EMBL:CDI78446.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Houghton {ECO:0000313|EMBL:CDI78446.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDI78446.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Houghton {ECO:0000313|EMBL:CDI78446.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HG670871; CDI78446.1; -; Genomic_DNA.
DR RefSeq; XP_013251321.1; XM_013395867.1.
DR AlphaFoldDB; U6GDV2; -.
DR EnsemblProtists; CDI78446; CDI78446; EAH_00033690.
DR GeneID; 25271439; -.
DR VEuPathDB; ToxoDB:EAH_00033690; -.
DR OrthoDB; 169704at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR CDD; cd00840; MPP_Mre11_N; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR007281; Mre11_DNA-bd.
DR InterPro; IPR041796; Mre11_N.
DR PANTHER; PTHR10139; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR PANTHER; PTHR10139:SF1; DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11; 1.
DR Pfam; PF00149; Metallophos; 1.
DR Pfam; PF04152; Mre11_DNA_bind; 1.
DR SMART; SM01347; Mre11_DNA_bind; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE 4: Predicted;
FT DOMAIN 392..568
FT /note="Mre11 DNA-binding"
FT /evidence="ECO:0000259|SMART:SM01347"
FT REGION 35..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 187..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 628..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..642
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 77170 MW; 78FAE76DE686D0DE CRC64;
MAESSYISGA LNARRLPVAA ATCSSSSSSN ILSQALQQNA ADAGEARGPP LFADGEGEGD
GAPVEAQERE EADENTFKIL IATDTHLGYK GEDPIRGNDS FRTFEEILQI GRRENVDFML
HAGDLFDENK PSRTTLYRAM CLLRKYCLGP GAVLFDVLST SNIQTPHRDT SQTHAYSSSA
ASATAATTVG SHSAASQGLH NGRMQQQQQQ TAAAAAAATE DPAATQMDPR GACDTFRFGL
NYLNENVNVC MPVFAMHGNH DDPGDASHLS PLDILEAAHL INYFGRVDDI EDIRIRPILF
RKGTSKASLA VYGMGWVRDE RLHRAYLSGK VTYEVPADEP VQNWFNVLLV HQNMYKGGHG
GVPAKNCVLE RMLPSFVDLT VWGACVFGGD SFRVKPVPLT TVRPLLIEDV CLADLLKDCA
SAQWKGGGPL QEGGIGAATA DKETWEVLTK VVEDMLLQYN AKRNAIIQQQ QQQQQQQQQQ
QQQQQEGVGG KCVNKKRQAY QLFCNYKSGA TQDLVVSTAN SSIPELQFEA ASANGPPDIH
DIIFHYMEDA RGLQVLLEPD FNDAVQRFAV KLDPSAISSF LKKSINTARL HARQLLREQI
QKSPNEMPSK EDVRGLICDF TQAARMKRLT EAEGEQKAEE DRGPSAAAAA LDSETAAAEA
AAAAAEERTE EGVVIDGFGA AARGTQRQQQ QQQQQRDIRS LLSQLLY
//
