ID   U6H5L9_9EIME            Unreviewed;       904 AA.
AC   U6H5L9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   03-MAY-2023, entry version 36.
DE   SubName: Full=Adenylyl cyclase, putative {ECO:0000313|EMBL:CDI87745.1};
GN   ORFNames=EPH_0050370 {ECO:0000313|EMBL:CDI87745.1};
OS   Eimeria praecox.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=51316 {ECO:0000313|EMBL:CDI87745.1};
RN   [1] {ECO:0000313|EMBL:CDI87745.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDI87745.1};
RA   Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA   Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA   Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA   Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA   Tomley F., Pain A.;
RT   "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDI87745.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDI87745.1};
RA   Aslett M.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HG708181; CDI87745.1; -; Genomic_DNA.
DR   AlphaFoldDB; U6H5L9; -.
DR   EnsemblProtists; CDI87745; CDI87745; EPH_0050370.
DR   VEuPathDB; ToxoDB:EPH_0050370; -.
DR   OrthoDB; 5490269at2759; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR43336:SF3; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43336; OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        23..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        68..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          571..727
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REGION          475..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   904 AA;  101291 MW;  B346669701081D36 CRC64;
     MDRSQRHSSV ASTRRGGQND SKFVSFCTFI AMHQVTEIVT TIATVYALFG NDLKLWATSV
     SADLPFDILT IICLVIFTLE IFVSCVGKEN YTWHTFFWFD LISTGTLILD LSWIYYEMYL
     VVEENAEMAS SDVMQVSRAG KAGSQVARVL RVMRLVRLIR VAKLYKTLAL RFQPKDEVPY
     QQDLFLEPGE RAPDDVGLEE EAEVVDDGGE YDSKIGRELT DRTTRKVIYI ILVMTIVLPF
     LSEDQYLSRT SSEQSGLDSV AESATAAKRY NTAPWWRMYS MNTVYYINYH RKHGIGYVEG
     EINPQNLVYM ELPLPLTHVT ESAGRVFVDM ACLGFKSCDH PLELPPQIAE EIILASAVNG
     TMLTDELESI DSLRPSEREI FSSAFCEGPS EEVAGPLVTQ KASSCVPQNI ATFKAVYDKR
     ELSHLECALS MLKTVFVCLI MVIGTVAINH DINTLILRPI ERMITKMNKI RNNPLAATNM
     NAEGEDRQSD ESADSAKGDP LQALKTWIGG KSSKTQKENY ETAILEKTII KIGGLLALGF
     GEAGAEIIAK NMHTADGNIN AMIEGRKMEA IFGFCDIRNF TDATEILKEK VMVFVNQIAE
     IVHGTVDQFS GSANKNIGDA FLLVWKFPER EIADGVKEQI IDTVTSNKLA DMAVMSFVKV
     VAGINKSHTL AEYREIPEII ERMGTGWKVK MGFGLHVGWA IEGAIGSEYK IDASYLSPNV
     NMASRLEAAT KQYGVTILIS SDLYDIMSPQ TQTYCRQIDR ATVKGSKVPL GLYTVDLDPG
     RLQVPNRTPV TVASKNTASL QRQQRLREKH KLWSSRTSIS AMFETDPDIV SMREHLTKEF
     LGTFRSGFRH YEAGEWYTAR EIFVRTQYML GVEDGPSTVL LHFMSTKNYV APEDWGGFRE
     LIEK
//