ID U6H6R2_9EIME Unreviewed; 787 AA.
AC U6H6R2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 08-NOV-2023, entry version 48.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=EPH_0075310 {ECO:0000313|EMBL:CDI87163.1};
OS Eimeria praecox.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=51316 {ECO:0000313|EMBL:CDI87163.1};
RN [1] {ECO:0000313|EMBL:CDI87163.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDI87163.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDI87163.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDI87163.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HG696857; CDI87163.1; -; Genomic_DNA.
DR AlphaFoldDB; U6H6R2; -.
DR EnsemblProtists; CDI87163; CDI87163; EPH_0075310.
DR VEuPathDB; ToxoDB:EPH_0075310; -.
DR OrthoDB; 5476523at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF42; DNA REPLICATION LICENSING FACTOR MCM5; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}.
FT DOMAIN 390..595
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 88301 MW; 72D8CA0A242DA728 CRC64;
MFEGERVYYS NNRSDPHGFE AEDGGPDSLP SLKQARLFFE QYLHHGSGAL RRKLLAEAEK
NTKCLLELDL FDLIEYQHRV QPADLECVNT PLCARDRHRA PADFAHRLAR CLRERPLVYL
PVCEKACEEI AAKSAIVQGA SDGPPSKRER TFDVQINLID SGKKPTPIRS LLSHQQEHFV
VTTGIIISCK APISRMQKIT IQCRFCNHKL VIHAAEWREQ PQLPRFCRYS ELAGPGQGES
DLGCKNKPEP YFIVSTECTF IDVQLLKMQE LPEDVPTGDM PRHLLLNASR FLVDEATAGD
RLLISGVLTT EASPSVTTFS TEKYEQTGPQ HAYIHVLGIR KINFSPLLST MTSLEQRSLF
QRLSQEPNII DKIARAGKGV QRMKLLRLFV TDLMSRSIAP ALFGMKEVKR ACACLLFGGT
AKIINDTTRI RGDINVLLLG DPSVAKSQVL KFVAKLAPIS VYTSGKGSSA AGLTAAVMRD
RQGVFSLEGG CMCLADGGVV CVDEFDKMQE RDVVAMHEAM EQQTISISKA GINTVLNSRC
SVLAAANPSF GSFDDAQDTT EQHEFKATIL SRFDLIFMLR DKDDYDKDTR LCEHILSLHA
RRAAPPPQEE GDTIPFELLR RYIQYARQQH QPLLSLDARD ALKNFYVQTR QDVREDRRSV
TRKIPITLRQ LESLVRIAES FARMELAPSA QASHVKRAID LFSASTAETA KHALVFESLT
PLQQKAIKLA EDALMSRLQP GQRALRRNIV RDLQQQGYDK LAVQRAISIL VRRGDLQERG
DRSIRRP
//
