ID U6K5E0_9EIME Unreviewed; 977 AA.
AC U6K5E0;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=EGF-like domain-containing protein, putative {ECO:0000313|EMBL:CDJ32980.1};
GN ORFNames=EMH_0049800 {ECO:0000313|EMBL:CDJ32980.1};
OS Eimeria mitis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=44415 {ECO:0000313|EMBL:CDJ32980.1};
RN [1] {ECO:0000313|EMBL:CDJ32980.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ32980.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ32980.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ32980.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the apicomplexan parasites AMA1 family.
CC {ECO:0000256|ARBA:ARBA00007098}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; HG684728; CDJ32980.1; -; Genomic_DNA.
DR RefSeq; XP_013355544.1; XM_013500090.1.
DR AlphaFoldDB; U6K5E0; -.
DR EnsemblProtists; CDJ32980; CDJ32980; EMH_0049800.
DR GeneID; 25379664; -.
DR VEuPathDB; ToxoDB:EMH_0049800; -.
DR OrthoDB; 202929at2759; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 1.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR003298; Apmem_Ag1.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR PANTHER; PTHR24044:SF498; PROTEIN EYES SHUT HOMOLOG-RELATED; 1.
DR Pfam; PF02430; AMA-1; 1.
DR Pfam; PF12661; hEGF; 2.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00815; AMA-1; 1.
DR SMART; SM00181; EGF; 7.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..977
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004672976"
FT TRANSMEM 876..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 484..518
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 554..588
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 659..693
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 731..764
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 765..801
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 903..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..963
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 508..517
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 578..587
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 683..692
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 754..763
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 791..800
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 977 AA; 102924 MW; B13C96EFF38C0228 CRC64;
MSRLVRLCGL LAPLFLISTF SPIPSSCHSV HNGVSATDYM NRFNIPANHI QLEWAKTGSG
LQSAVYKGKT YKWLPRNQTA GVKVGYATMW DRSSKGYCTR SDAEVDTQRY LGQRLMAVGA
CPNYGKYIAF VDRSGNPVDD EDRFTNEIHG NTMPFSTQGC SSSASRGTSE VPMDKSGWSM
YSGYLVKCPF NQAVYQNDML QDAEYDPSAC SFVTLDNPLV FLDTSLPGTS LAEKAYAFHG
KGGHQGYDFI GNGVGCPPYS PPLKTRSMKS PTLANDPFLC SQLSRCTSMC WPWDTNRPCY
RSLPASFNHS TSECLILGYH TQTYMGSNCA VKTATDSNAK YCVKAHKTVE SSKYTYVSAF
TRPDYETACP PREPLKNVVF GTISGGVCTP LKVASSSTGT AGACGEAVFE ASSDDSPSGV
GGTGSSSIFW SSWLPDGSSG QKGTCNMYST VPTCIFKVEG AISFTALSAA DPSLAKEPPS
EAILPGPCSS NPCKNGGTCE LPSGTCKCPA CFTGANCETP VSGCCSSDAD CNGHGSCKSN
KCKCNAGFSG PMCESGACDT VSCLNGGTCQ MPNGICVCPE GFTGSRCETS ACEKVVCENG
GECEMPSGKC KCPACFSGDH CETENPRCCE TDSDCNAPQG TCVYNSCQCA PSITGDKCDN
SGCTGVTCLN GGVCNDLTGH CRCPKCYSGL NCEIFESNCC ESDSDCNEPN GVCNSSNTCE
CAPEFPAPNC KDLCSATQCL NDGKCDPTTG NCTCMPGWGG KDCAVPEPCG ESGEVCSGNT
ACDSEKLTCV CKPGYIGEDC TEMSPECSDL CKVGGDILRD SEGECRLDCY STCCKHLTET
CKEQSDEDKE QCIRDSLGAT EEEACCLARV EEGSNVAMYA ALGVIAALLL LGGAGGMYYN
NSRGQSASSG PSENPIDETV GGTDRPARAE SAISVDFDDY ASTPDDAPGD IHAEGEAAQD
AEWDGKPDAT QASSPSP
//
