ID   U6K5G4_9EIME            Unreviewed;       915 AA.
AC   U6K5G4;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=Reverse transcriptase domain-containing protein {ECO:0000259|PROSITE:PS50878};
GN   ORFNames=EMH_0079620 {ECO:0000313|EMBL:CDJ33040.1};
OS   Eimeria mitis.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=44415 {ECO:0000313|EMBL:CDJ33040.1};
RN   [1] {ECO:0000313|EMBL:CDJ33040.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDJ33040.1};
RA   Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA   Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA   Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA   Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA   Tomley F., Pain A.;
RT   "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDJ33040.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDJ33040.1};
RA   Aslett M.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HG684796; CDJ33040.1; -; Genomic_DNA.
DR   RefSeq; XP_013355604.1; XM_013500150.1.
DR   AlphaFoldDB; U6K5G4; -.
DR   EnsemblProtists; CDJ33040; CDJ33040; EMH_0079620.
DR   GeneID; 25382389; -.
DR   VEuPathDB; ToxoDB:EMH_0079620; -.
DR   OrthoDB; 4271330at2759; -.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.10.20.370; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 2.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
FT   DOMAIN          375..559
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..167
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          266..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          821..915
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        821..840
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        860..915
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   915 AA;  103831 MW;  5E54E7BD7934EB1B CRC64;
     MHSLPVLRKE GERPDGNTSK KEALKTETDC AYEALAHQIS QMTAEEAAVF LRPTPKRYKT
     KTRRKRGIQI KDLINHARKN TEDYPLNAPS TIESSLYQES YPLRLPFTKC HQITCFITLK
     RFSGSAPEGQ SRLLCTILAC SAKTRDRTRN DNRPRDNNEL EDTEESPAYE ALAHQISQMT
     AEEAAVFLRP TPKRYKTKTR RKRGIQIKDL INRARKNTEV MKGATEGLNC IIMVPETGVV
     LDKHEPTEGQ SRLLCTILAC SAKTRDRTRY DNRPRDNNEL EDTEESPWPN ARLEFTEFDK
     WIESEEAREL PLPVAHLLRQ YRLLFPDSLP NGLPPKRPFD HRILLIPGKL PTRAPIYKMP
     PDHMLHHSQE IQRLCAKGWI GPTYSPICAP TIMVDKRDDG SGTRKMRMVV NYQALNSLTI
     ATEFPMPCIQ TVMELIGGAS YFSTLDLEAG FHQIRMARED RWKTAFRSIQ GLFEYKVMPF
     GLKGAPATFQ ANINAYLQPL LGHGVIAYID DVLIYSKTLE EHTQILRQVL DIFLKHQFYP
     KFIKCRFAKR ELTYLGYTIG NDGIKPAADK VEAIQQWPET LANETQVRQF LGTVNYCRMF
     MGPRYADLAR PLIELTRRNA PFVWTEEHSK AVRQLKQRLS EFTILQVPNP TKPFKHSKAV
     RQLKQRLSEF TILQVPNLTK PFTLYTDASG YAVGAVLEQD NKPVGFLSQV MTPTQQKYSI
     YDQELLALIS ALDKWRHLLR GAKVTVYTDH QALTFLQRLS SQKPLRGRTA RWLDFLAEFS
     DLTITYLQGA KNKVADALSR HPRHGSGEPN RVENILATMV QQQGTSAAQP RYSTRLVTGS
     ASHPDFRAMI GRRLPMRQQR KNGSESQQAA GSAGTNESQQ PAISAGANES QLEAGSADAN
     ELQQATGGSS LHVSI
//