ID U6KFT1_9EIME Unreviewed; 2365 AA.
AC U6KFT1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Protein Abca14, related {ECO:0000313|EMBL:CDJ35112.1};
GN ORFNames=EMH_0070910 {ECO:0000313|EMBL:CDJ35112.1};
OS Eimeria mitis.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=44415 {ECO:0000313|EMBL:CDJ35112.1};
RN [1] {ECO:0000313|EMBL:CDJ35112.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ35112.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ35112.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ35112.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; HG687766; CDJ35112.1; -; Genomic_DNA.
DR RefSeq; XP_013357674.1; XM_013502220.1.
DR EnsemblProtists; CDJ35112; CDJ35112; EMH_0070910.
DR GeneID; 25381604; -.
DR VEuPathDB; ToxoDB:EMH_0070910; -.
DR OrthoDB; 6951at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF36; ATP-BINDING CASSETTE SUB-FAMILY A MEMBER 5 ISOFORM X1; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF13405; EF-hand_6; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00054; EFh; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 182..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 260..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 664..687
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 699..723
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1549..1571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1592..1618
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1630..1650
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1657..1679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 891..1130
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1839..2077
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 2217..2252
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..883
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1306..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1777..1798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2365 AA; 261098 MW; 4517476CF3DB7FB3 CRC64;
MISASTAPLP RTAPAHSSSS LSTGPPGPPS DPGAAGGFSE ARPRRAETAQ CSIPNFQRQE
ALPPNSLPTG PHGDMHGARG RKRDSEAGDA YKTCSACSPK REGDLGGVIQ EYQKENLDAQ
SYSSFVLTEC PALEPTEAFQ QLRKPPILRA AFFRGAAKLS AETDRIFVLL WRAFMFRFRY
PIMTLIGLLV PVALVASACT ILAHYQDVEL NYVPTNMTAR RHMVCNFAAY INRTRVVKVD
SNLCMPPSNM MGSFGRRYDG LHMMYLPLVL HYGGFLAFVD KGGSDCQQLR LFMEKFAETV
SPYLMRRTTA EDLFITFPSE KALDKYRRAA AAEKKRPIHS AFICRATAPG QLDVTIRMHV
RRGTPRSFAN DAIKFLRRHY TSYNSTTYFG GASFLLHTDV VGTPDEGEPY GHLTGGFLDL
LTLAHVFNMD RTKVRELPEH SPVSQDFQSQ WERISEAFYR MFHYFGRIPV IDSVALSRNR
RGLVNSFVRD AERHLSEMLA LVICISAANG QADPPGLSHV YRHLLPAWVL GPGYGVVRLF
TRRAAASGCD PSSSSMQLLE KVFYSRTQKM GLGLIMAAVG PLQAILRNVS APVRRAYSPV
NFLETAMPFV PATVISRSEK PHSCAAPFVV LFVCILWQVV KAIMVDKETG FKNMLKILGI
SDRVLWTSWY LFFTLYNLPT LVAVAYISHY FAFQLSDIWF IIFLFMLGLV ASISFALFVT
ALFMDGNLAA MAACAWYVLI WVPVVCQRFG SAAWDPHLQR LFMAICPAAA LGVGIDIAWN
FNEPYIGGIR SSTINTSSLG ITLADTYITL GISIVLFTCL GAYLHKVKPT SSGSPAHPLF
FLFPILSCIR RPCTLCSRRK QPKDSQELQE ASAGPFCGEN RGGENDGKPL LEVRSVHKKF
RTWQTKKCSR GSVKAVRGVS FSVYRNEIFG LLGQNGAGKS TLISVITGSL AATSGDVLID
GVSVKQYPSL ARCNIGYCPQ FDVLLPYLTI EETLWLYAAL RGIPRRRRKE EVAELMNMMK
LSEMAKVQVV ALSGGWRRRV SSSVAFLGDP TIVFLDEPTA GMDILYRRTF WDSVRGLSKG
RCIVLITHMM EEADYLCDRL AIMVDGVITS EGTALSLKSR FGSGYIISVI LLKQAEPEVQ
QANKKLRQLL QTFEHPPAIT EISRHELRIV CPFSHSFQLP RLFSELEINA NYYGVECAVL
GFASLEEVFL NVVKLAARGG ASESTGADEA TNPNRLSLAN NAAQNGVELN PPVGSANGRC
SSSSRRVSAT LRRAAVDPAE CADHVAATAP QPLALRCTDS GFESCESKQA GGAPRSSSSA
SAIPSDPNAI PHSSACGSSW LAAHQKRGRA RRGLLWQLAV LRALVAKRIR LLYRDWALVT
VSFLIPLLLM GLTLYLRSAK SEPRVPLTGQ QLFEYRLPKG IHSEVPYGGA GWILGALDDC
YSPFMTHNNV SEHVKDNNDM YGFLLDGYFG PHDPRFGAYV APPGQADISD ETSQLEVTIW
HNSTFRDSIP LHYSHLLNCI AQQRTGMTDS VFVSNQPFED TDDKSMDGLV VGFFTVIAYS
FVAAGVGKVC IVERVRKVRH QQILAQVTPF QYWISSYVVD MVLLLLPCSL IFGMMLWVDI
TPLVGPHQRG AFLLGTALFC FSVCPLGYAI SMGLDSAMTF VIVMLLLGWS LPSIQALFTE
VSGLQGMYNQ YLRYAFMLLP HAALCELLTN LAMMNQLVGG KMQAEELVNW MEFSKTGCPL
LYLGLTILLN WMEEEMKAGK AVQQLRRRFQ HRDLSLSSGS HIDSEDAGRD VEESQNPSSL
GLPYCATDGV ELPLVVHRLE KTYPPPIMQR CLCCCCPQTR SSCWPFCLSC KRPQPTRALK
GVSFCVPRGK CFAYIGVNGS GKTTTFNIVG SLMSQTAGSV FIGGYDALLQ TEKARAKLRY
CPQSDALLPT LTGAEHIYLY GCLLGLRRHQ LRDFCSDFFN VIGCSKYMHT LVKSYSGGTK
RKLSLGIAML GKVDLLLLDE PTSGVDPESR QVLWRMIENA KNCQTSGKAI VLTSHSMEEC
EVLGDRVGII HKGSMLCVGT PAELRSTYGH GYQIECVFVA ASVSQDPSLP RRFISALQKT
LPTLRVLHRM AYKVTASVAK GAVSLATIFC EVEAAKAPFA LEAYVVSETT LEEVFVEVSL
RADGKAQTLR LRLPPQFGGI WRAGPVRSDE DRLDEGVLQQ TDTISNMSGP PFGLSSQRRK
ELQVAFHAFD KDKTGKLDVN EMKYLLKSIG VCLSRREQKA LEAEFADRGE FDFEDLLTIG
QVVYNDVAIE RALVLALRKL TPKGAKTVSR TVLRDMLLNL GMGVKLTEEQ VDMFLDICCS
EDGKRRSYAT DVKGTGGVAA VITLY
//
