ID U6KKE7_EIMTE Unreviewed; 2357 AA.
AC U6KKE7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Adenylate and guanylate cyclase catalytic domain-containing protein, putative {ECO:0000313|EMBL:CDJ38374.1};
GN ORFNames=ETH_00026685 {ECO:0000313|EMBL:CDJ38374.1};
OS Eimeria tenella (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5802 {ECO:0000313|EMBL:CDJ38374.1};
RN [1] {ECO:0000313|EMBL:CDJ38374.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ38374.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ38374.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ38374.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; HG673835; CDJ38374.1; -; Genomic_DNA.
DR RefSeq; XP_013229212.1; XM_013373758.1.
DR EnsemblProtists; CDJ38374; CDJ38374; ETH_00026685.
DR GeneID; 25254433; -.
DR VEuPathDB; ToxoDB:ETH2_1344200; -.
DR VEuPathDB; ToxoDB:ETH_00026685; -.
DR OMA; CDEQVPA; -.
DR OrthoDB; 199822at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR24092:SF219; GUANYLATE CYCLASE ALPHA; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 398..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 431..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..499
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 511..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..564
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 584..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..877
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..908
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 935..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..983
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1659..1680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1700..1719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1731..1751
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1877..1895
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1907..1926
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1932..1951
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1045..1221
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 2004..2138
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 41..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1277..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1336..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2199..2229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2248..2357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2252..2281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2343..2357
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2357 AA; 261430 MW; 80A4C4CB6D5D3E45 CRC64;
MSIVLRPAGW TEGAIMYAKG ADTAMLPLLS SFDGMLQESR TGAKYEGGPD PQDTQYAESR
FSRSTTTMRD GADRQNFPRV APAGSVPYNT PREANQNFAF SSEQAEPFKP CPAPESRVEA
DVELVEQHLK VFSLQGLRTM VLACKYMSQD ETDAYQRLYN DACSSVYSRE ERLEQVAEQF
ERDLEYLGIT GVRDKLQAYV PETLELMMEA GIRVWIATGD DVEYALHICH SCRLLTSHTK
VFHAALATRG KRAKREGMLL YDMFREARIL KRADEHICLV VTGPNLAAFL NHPDLQTCFL
NMACCCDVVV AARVTPTQKA DMVRLVKKRL TPQPITLAIG DGSNDVPMLQ EASVGVAIRT
ERGTSVAGFA DFAISEFRFL QRLLFVHGRL NFLRISKVIL WTFFKSILLS FPVFLFQPSA
FWSAVELFDP VLYMLANFLW TVLPAIVYSF SEQDLPEHLL PSIPVLYTLG RRRLYFNGFT
FSFWTVEGII YSLLTYYILQ AAWMDSNAIP GGQTMGFFSF GAILLFGLII QSNLRMLMET
HLWTPTFILT TVGLCTLIYI PVLYVYSAIG WPSRGMLGVA SEVFAWPLLY FVVLLWIGVG
IMLQVLLAGV KSSLFHNIAN NVKQWLAQRQ VEHDKRRRVT GLPFGEPRLR LLPGGQDEYG
PFCGTSSLLS AVKRLLWVCG FGACLPAPGP VHQLVDRRIL AFLRDKFNPL RHSEVSTKLP
PPRRFRVNEN FVTYGGDKKE KDLGAQEKDG GGSHGRGGGA ADDVSMDSNS SGVSFEGDKH
RDRVKLVKVS HLINRFSLKF KDMQLEADYQ IHQKKSFVKR LVPWYRVIFV FLGLYRIVAF
LAEYFIDAYW GTEKRVTPWM CIPTVIVVLG LLGATLSTFG QFFMDHFSFV LSSVIFLMLA
EHVTLYAAAK MDGILSSLLF PVFTFVILRI SFLQAVMWNI FFVLAFTIRY IIGQSQSYLS
LSDLYDHLPL FLGSIVFVGF VGYRLEYNQR KSFLLDYSVE ASRRKQREIL NTMLPPFVVD
QMINAPLNED GIPSTLEAED RGTVSVVFCD VYEFQQVVAS IEPTRLVEVL DSLFLCFDKS
AEQFGCTKIE TVFETYLAAA GLQPGKGSES DTSQTDAGDA LDMALAMLEV AAQIRYEVTR
DLANAVGTND EEQAHAAARM SSSVMTRQKT ATLRTVLSSR PQRIRVKIGI NSGRVISGVV
GAKKPQYALF GDTVNTASRM KTTGQPDYIH ISESTYDLVK DDTTLFYEAR KTPVKGKGDM
NTFLLVRVMG SSYPNFGEDE RSLSGPLGSK DGALNPFGQG SASLGGERIP TVWPGATNVG
PPSNEAIIPS VASFSRERQH TQEFPGSVAQ SIPSTPRLTP GLTSRSSLSE SISPPEGSSP
RTPSIHSLER SLSRGQRSYS TMSSSEAGAI SMTPQQLTRA YARQESVSRV LAFARDGLQT
AVRESSELKR QEIARQVHAQ ILREQLHQGS SSVWSSQEDM SVGSNCLSTN VASLPQFRYA
ASHTADIRNS SRIGRSISSS TRQSPRQTVA KRAVSESRAL EMRNSRTDVT EPSLTTQDSS
GQRSLGMWRA ANDLFAHIGT EAHAKISVLL KVLGNTGKEE EHAADIGIDD EDNFEARDAR
IGASRESLLL MKFKDKNLEA RYRTHFYNNK SNINTIEQAI IIFLVAFAVQ TLVRLCLPWN
YTEVVDGVKY TIKVSSRLYW GVRATYTCVA FLLWILFHYR NRGEVASRLE IRWMVFLLNI
LFISAACVFA LSNSWSTETT TRQSATSFSS GTAASVLSPG VALETSALGT DMLTYIGGIS
SVRMPSNVAQ QSPVAFLTGK SPRSGLTYKE NCPTGVCQTS SPTDEAPLIW RRLGAESSSP
EPSSLTVTVE VPGQRGASFW LVADSVELFF YVVILHHNTG LLFQNCILFD ILLLTTCLTF
ILTAAVSTSN TIGMVVNFPC YVFFNLVSAY WKEYIDRLTF YVNEHAKTTE GRATQLLNDM
LPKQVLEEFQ QDKLRLAYTH DRMTFLFADI CGFTSWAKNV DACEVVTMLQ KLFAKFDRDS
TKYKLYKLCT IGDAYVAVSE PVTEDNEDYD PVEGTGLVLT MAQSMITNIQ EVRERLNIPS
LNMRIGLHYG TCVGGVIGSG RLRYDLWGMD VLTGNMMESN GQPGKVNVSA ILRDFLLKHF
PGKFQFRFNK SVCVINKTVD SYIIHPAGEA TDEDAIAQPD GAVLPPQGVA APVPRRDDSS
RQDIRGRVSR RGSIIGLHRA LGRRCSVRGG FENSAPTESP RISGPSVSRP ASRTSSRPSL
VPQEEALDEG FNRQQRDVEG AATGGAGGAP ENVALQPLKK ASSAGHSSGV GMQPISEEGA
ALTPSPDYNS ESSPEIY
//
