ID   U6KLZ3_EIMTE            Unreviewed;       767 AA.
AC   U6KLZ3;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 46.
DE   SubName: Full=X-prolyl aminopeptidase, putative {ECO:0000313|EMBL:CDJ39001.1};
GN   ORFNames=ETH_00029300 {ECO:0000313|EMBL:CDJ39001.1};
OS   Eimeria tenella (Coccidian parasite).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=5802 {ECO:0000313|EMBL:CDJ39001.1};
RN   [1] {ECO:0000313|EMBL:CDJ39001.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDJ39001.1};
RA   Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA   Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA   Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA   Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA   Tomley F., Pain A.;
RT   "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDJ39001.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Houghton {ECO:0000313|EMBL:CDJ39001.1};
RA   Aslett M.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M24B family.
CC       {ECO:0000256|ARBA:ARBA00008766}.
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DR   EMBL; HG674134; CDJ39001.1; -; Genomic_DNA.
DR   RefSeq; XP_013229756.1; XM_013374302.1.
DR   AlphaFoldDB; U6KLZ3; -.
DR   EnsemblProtists; CDJ39001; CDJ39001; ETH_00029300.
DR   GeneID; 25254953; -.
DR   VEuPathDB; ToxoDB:ETH2_1328100; -.
DR   VEuPathDB; ToxoDB:ETH_00029300; -.
DR   OMA; LVDQAWG; -.
DR   OrthoDB; 869at2759; -.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   CDD; cd01085; APP; 1.
DR   Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR   Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR   InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR   InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR   InterPro; IPR000587; Creatinase_N.
DR   InterPro; IPR000994; Pept_M24.
DR   InterPro; IPR033740; Pept_M24B.
DR   InterPro; IPR032416; Peptidase_M24_C.
DR   PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR   Pfam; PF01321; Creatinase_N; 1.
DR   Pfam; PF16189; Creatinase_N_2; 1.
DR   Pfam; PF00557; Peptidase_M24; 1.
DR   Pfam; PF16188; Peptidase_M24_C; 1.
DR   SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR   SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:CDJ39001.1};
KW   Hydrolase {ECO:0000313|EMBL:CDJ39001.1};
KW   Protease {ECO:0000313|EMBL:CDJ39001.1}.
FT   DOMAIN          13..136
FT                   /note="Creatinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01321"
FT   DOMAIN          408..668
FT                   /note="Peptidase M24"
FT                   /evidence="ECO:0000259|Pfam:PF00557"
FT   DOMAIN          679..758
FT                   /note="Peptidase M24 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16188"
SQ   SEQUENCE   767 AA;  84739 MW;  C075026AAB8C217A CRC64;
     MVSRGVDAAA AERLGALRLL LQAHQLDGLI VDDADAHGSE IPARAFARRT FLSNFSGSNG
     LALVTRDSAF LWTDGRYFSQ AEQQLPVGLW QLMKSDFGNT PTLTQFLKQE TKIRRLGVDA
     FTTSLGLLSQ IKEAGFNVQR EAQTHQGSQD ASVRHIIPLD QNLVDEIWGV QRPVLPSSSV
     YAHPKEFRGL STREKVARTV QTMAKEGADL LLLSSLDEVA WLTNLRGSDS PNSTVFYSYA
     LLAKGPNVAS TEDPHCAKPC PWRLLVYTDP TRVSSSAKAE LETEGAVLRP YESLASDLQL
     LLTWNLRQQQ QLLQREHQQL PEDLQQQTHG GLLGAVDWLL AGGDETRHEP RSKLQITGAL
     DERRAAWLDP KINLAIHRIL ADSKRLIVKD TPVSVAKAAK DEKELKGMAE AHEDDGVALA
     TFFCWFEKQL LANARATMTP PQQQEHGGQE CSLTEWTLKE AVDASREAMS DLFRGTSFAS
     ISCFGSNCAL AHYRPDPETS LQLKARMSEP QGLLCVTVRG PGGDPPAQNE SPVFLLDSGG
     QYLTGTTDVT RTLHLGEPTD EQKEAYTLVL KGMIGLSAQK FPEGSKGPQI DALARQHLWN
     RGLDYMHGTG HGVGHFLNVH EGPIGISPRL TGAASLHEMQ PGAVLSIEPG FYKDKAFGIR
     IENLAAVKPS GLSHRGRRFL EFDSLTLVPI QARLIDASLL TRQEIAWLDA YHQRVFTRIS
     SRLTTKGKDF PFRPPLPQAV SVTSEEVRLW LKKNTQPLHE LLQTEWP
//