ID U6LB30_EIMTE Unreviewed; 762 AA.
AC U6LB30;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Diacylglycerol kinase eta {ECO:0000256|ARBA:ARBA00017201};
DE EC=2.7.1.107 {ECO:0000256|ARBA:ARBA00012133};
GN ORFNames=ETH_00023780 {ECO:0000313|EMBL:CDJ44940.1};
OS Eimeria tenella (Coccidian parasite).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX NCBI_TaxID=5802 {ECO:0000313|EMBL:CDJ44940.1};
RN [1] {ECO:0000313|EMBL:CDJ44940.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ44940.1};
RA Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA Tomley F., Pain A.;
RT "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CDJ44940.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Houghton {ECO:0000313|EMBL:CDJ44940.1};
RA Aslett M.;
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Phosphorylates diacylglycerol (DAG) to generate phosphatidic
CC acid (PA). {ECO:0000256|ARBA:ARBA00002064}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase family.
CC {ECO:0000256|ARBA:ARBA00009280}.
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DR EMBL; HG677862; CDJ44940.1; -; Genomic_DNA.
DR RefSeq; XP_013235687.1; XM_013380233.1.
DR AlphaFoldDB; U6LB30; -.
DR EnsemblProtists; CDJ44940; CDJ44940; ETH_00023780.
DR GeneID; 25253868; -.
DR VEuPathDB; ToxoDB:ETH2_1105300; -.
DR VEuPathDB; ToxoDB:ETH_00023780; -.
DR OrthoDB; 216012at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004143; F:ATP-dependent diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR037607; DGK.
DR InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR11255; DIACYLGLYCEROL KINASE; 1.
DR PANTHER; PTHR11255:SF34; DIACYLGLYCEROL KINASE ETA; 1.
DR Pfam; PF00609; DAGK_acc; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00045; DAGKa; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:CDJ44940.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 347..457
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 604..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 762 AA; 75960 MW; 5214601C4BCD0B3C CRC64;
MGAPQQQRGS LVGPRGPPFS PFSFLLIFLY LILSPLVFLP ILGGPSGVSF AAAGPADRGS
PAAAAADPSA AAAAAAAAPA AASAAALPGG AGAAAAAAPA AAPAAASAAA PAAAAAEPRA
AAAAAARAAP SAAGAAAGAA AAPAAAAAAG AGAAGAAAGG AAASSAGAGR PRSRTAAAAA
AAAAAAAVRT PPGSVAEAEA AAAKWVCGPD TNLYFFIANP TSGDRLGEKF LKRLPLGAAA
IGCSSVMVFS QKDAASMSLA LRYIAAAAAT RELLHLGRQQ REAAEAAAAA AKAAAKLQKA
RAAAAGGGAG AAAAAAGAEE AAAAAAAAAA AAAAAAAGGA AAVPLSDRVR VIAVGGDGAF
NGMLQSLKSF KLVENEKEIN KNKKNRNKTF QNINLNFVAA GIVPSGTGND WANSYGWTRA
SFPRKNPLRR KNFTRLLNTL ESSVLAQHDC WKVTVAAKKG FRAFSAAAQQ LQQLGPDRHG
SELKKTFFMS NYFSLGFEGL VGTDFDRVRG SSRLWNRGVY FFLFLRHLKT KPFLCSRIDT
IYSFNPNFVA LLSNSSRYTR VPSLKPCVSI TFMNSLTMFG GIKMWGPSMK VGLEPPAVLS
GLLGAPQGAP QGAPQKAPEG APEGAPEGGG GAAAGAPEGA AEGMAAGEGS PRKPAAAAAA
AAAAADYSLY LKELLAARQD PGDGKVEVFS MGSTVDYVQA QAVGANAAQR LLQGKGPFFV
TFKDEEEKEM PIQVDGEFYL VGGIESVLVQ RLGAFGVLQY VQ
//
