ID   U6ME12_EIMMA            Unreviewed;       661 AA.
AC   U6ME12;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE            EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN   ORFNames=EMWEY_00007510 {ECO:0000313|EMBL:CDJ60679.1};
OS   Eimeria maxima (Coccidian parasite).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC   Eucoccidiorida; Eimeriorina; Eimeriidae; Eimeria.
OX   NCBI_TaxID=5804 {ECO:0000313|EMBL:CDJ60679.1};
RN   [1] {ECO:0000313|EMBL:CDJ60679.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Weybridge {ECO:0000313|EMBL:CDJ60679.1};
RA   Reid A.J., Blake D., Billington K., Browne H., Dunn M., Hung S.,
RA   Kawahara F., Miranda-Saavedra D., Mourier T., Nagra H., Otto T.D.,
RA   Rawlings N., Sanchez A., Sanders M., Subramaniam C., Tay Y., Dear P.,
RA   Doerig C., Gruber A., Parkinson J., Shirley M., Wan K.L., Berriman M.,
RA   Tomley F., Pain A.;
RT   "Genomic analysis of the causative agents of coccidiosis in chickens.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:CDJ60679.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Weybridge {ECO:0000313|EMBL:CDJ60679.1};
RA   Aslett M.;
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR   EMBL; HG721904; CDJ60679.1; -; Genomic_DNA.
DR   RefSeq; XP_013337329.1; XM_013481875.1.
DR   AlphaFoldDB; U6ME12; -.
DR   EnsemblProtists; CDJ60679; CDJ60679; EMWEY_00007510.
DR   GeneID; 25334737; -.
DR   VEuPathDB; ToxoDB:EMWEY_00007510; -.
DR   OrthoDB; 216971at2759; -.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR045194; MGRN1/RNF157-like.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR22996; MAHOGUNIN; 1.
DR   PANTHER; PTHR22996:SF0; RING-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR   Pfam; PF13920; zf-C3HC4_3; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT   SIGNAL          1..45
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           46..661
FT                   /note="RING-type E3 ubiquitin transferase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004676077"
FT   DOMAIN          496..533
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          229..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          568..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          172..202
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        568..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   661 AA;  69107 MW;  9681330C80B8BB6D CRC64;
     MAASAATAAA AAAAAAGAAV SRSRRGLSLV VVVAVLLLLL RPSAANAAAA ASGAESGGMT
     PAAAMSAAAA AAGGSSISSS SRSNDNNNDS SSNSSSLIYD VELSPGAHNV MEALLLAGFG
     RYRYELQQLM RVHFTKLLQH NKPAAAAAMP LVEVKVYCYD PLPLNQGEVQ ENEEHQQQLL
     LMQQQQQQQQ ELQQELQQEM LLLHQTDSTG HSSSHNSFFS PIVAAYSSSS SRRERNSNNS
     NLQQREALLS SPSSTAAAAA AASTSAAAAA AAALAGGGFE VSVDAAATAA VRAYWGVGQK
     AMETFIKGNN NSDGQSLLSG SARRLARLLP SSSSDSSSSR RFNTGTFAAD SAAMPWGPDG
     CCLMSAPQIV PAGRGHRLRF FTHDRDNTAG RLSPFTEAVF PLVIVASVGG SSATCHLLLL
     RCRPLPPPPP STSSRSRVSA AEAAAAAAAA PLPACYVSHR YEVYRQLLAG GSLDKPQEKG
     DIFGVSSSSG TLDLECLVCM TNPKNVVLYP CRHCALCLEC LQALHQEKCP VCRSHFFGFI
     TFPLSKNLTA AESVSVAPAA AVADSRNGVV SSGSSNNGST NVQHHRGGSR VVPAETQMET
     VTKYAALFRL LVVLQEAAAA TYFVTVSMPL EARQEAGTVQ QKQQQQHCST QLHNVRYSAV
     A
//