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Database: UniProt
Entry: U6NLY9_HAECO
LinkDB: U6NLY9_HAECO
Original site: U6NLY9_HAECO 
ID   U6NLY9_HAECO            Unreviewed;       951 AA.
AC   U6NLY9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 28.
DE   SubName: Full=PAS fold and Ion transport and Cyclic nucleotide-binding domain containing protein {ECO:0000313|EMBL:CDJ81516.1};
GN   ORFNames=HCOI_00482400 {ECO:0000313|EMBL:CDJ81516.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDJ81516.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDJ81516.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDJ81516.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HF956589; CDJ81516.1; -; Genomic_DNA.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005622; C:intracellular; IEA:GOC.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   CDD; cd00130; PAS; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR018490; cNMP-bd-like.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003949; K_chnl_volt-dep_EAG.
DR   InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR000700; PAS-assoc_C.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF13426; PAS_9; 1.
DR   PRINTS; PR01463; EAGCHANLFMLY.
DR   PRINTS; PR01464; EAGCHANNEL.
DR   SMART; SM00100; cNMP; 1.
DR   SMART; SM00086; PAC; 1.
DR   SUPFAM; SSF51206; SSF51206; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   TIGRFAMs; TIGR00229; sensory_box; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS50113; PAC; 1.
DR   PROSITE; PS50112; PAS; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Ion channel {ECO:0000256|SAAS:SAAS00904115};
KW   Ion transport {ECO:0000256|SAAS:SAAS00502700};
KW   Membrane {ECO:0000256|SAAS:SAAS00502630, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00903208};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00904256};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00903350};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00137614,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00137754,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00502637};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00903851}.
FT   TRANSMEM    218    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    352    376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    426    447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    454    474       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       12     90       PAS. {ECO:0000259|PROSITE:PS50112}.
FT   DOMAIN       93    145       PAC. {ECO:0000259|PROSITE:PS50113}.
FT   DOMAIN      557    658       Cyclic nucleotide-binding.
FT                                {ECO:0000259|PROSITE:PS50042}.
SQ   SEQUENCE   951 AA;  108073 MW;  A77FBAECE6CF6C0C CRC64;
     MPVAKRGLVA PQNTFLENVI RRCNNADTSF ILANAQVVDY PIVYCNDGFS KLVGYSRAEI
     MQKPCSLAFL HGDHGEASNF VRIQEALDNG RTDQAEIGLC KKNKTPIWLL VHLAPIKNDK
     DSVVLYLCQF KDITPLKQPL DDENNKGLSR ILQIARIAKS KQQFNQIETK DLHKTTTSAS
     SNFTQVMNLG GDMLPQYRQE TPKTSPHIIL HYSTFKTIWD WSILALTFYT AFMVPFNIAF
     KNREYPGGGI DSVALMDSIV DVIFFADILL NFHTTFVGPG GEVVIDPSII RQNYFKSWFL
     IDLLSCLPYD IFYMFKRDDE RIGSLFSALK VVRLLRLGRV ARKLDNYLEY GAATLLLLLC
     AYVLVAHWLA CIWFSIGEYE VRIKMDNPLL PDGWLFRLAN DLKSPYNINL SNRTRLVGGP
     SRTSSYISSL YFTMSCMSTV GFGNIASTTD NEKVFGVCMM IISALLYAAI FGHMTTIIQQ
     MTSATVRYHD MISNVREFIK LQEVPKELAE RVMDYVVSTW AMTKGIDTQK VLGYCPKDMK
     ADICVHLNRK VFNEHSCFRL ASDGCLRSLA MYLESNHAAP GDLLYHTGES VDALWFVVSG
     SLEVIQDEEV VAILGKGDVF GDEFWKNNGS TGQSAANVRA LTYTDLHMIK KDKLMEVLNF
     YKAFANSFAR NLVLTYNLTH RLKFRKVVDV KREKELDARR KNEKLTLPPD HPVRKLLFRM
     RERHGPRIFP SPMFADIEKG MKKHPATTEM NRVSSVHSMV DETSNLLSSS YPSRSPRNGQ
     KNKRPPLLKR QTVDEDAFSR TSWGGAPGDL KHKDKDWVSL NNIRSEMRSK FEVIHDRLGM
     VDQINSRLQN MERLLMQFMQ NRGGHTPSTM PATSMMVLNE TSGSHLESPG NFVARSVSWN
     QDETWRPVPP LDELKNVEWN SDDSPSGVPV IQVDDDSTTR AIHRAPDRRR I
//
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