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Database: UniProt
Entry: U6NSD9_HAECO
LinkDB: U6NSD9_HAECO
Original site: U6NSD9_HAECO 
ID   U6NSD9_HAECO            Unreviewed;      2441 AA.
AC   U6NSD9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 19.
DE   SubName: Full=Inositol 1 and MIR and Intracellular calcium-release channel and SPla RYanodine receptor SPRY and Ryanodine receptor Ryr domain containing protein {ECO:0000313|EMBL:CDJ83441.1};
GN   ORFNames=HCOI_01965300 {ECO:0000313|EMBL:CDJ83441.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDJ83441.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDJ83441.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDJ83441.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HF959059; CDJ83441.1; -; Genomic_DNA.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Receptor {ECO:0000313|EMBL:CDJ83441.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN      121    175       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      182    226       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      236    290       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      296    353       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      361    419       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      599    820       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1025   1231       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1495   1707       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   2441 AA;  277102 MW;  B8C0B8E47F794ABD CRC64;
     MDYDSIAEFR EDNQYVMKHF DYKCLNVERL ILILEFKGDI VCLSCIASHN RDGVLGSERV
     CLCTEGFGNR MCTLENVSDK DIPPDIAICM LYIDNALSMR ALQEMMSADS EHKSASGAGG
     HKTLLYGHAV QLKHVQSEMY LACLSSCSSN DKLAFDVGVQ ETNEGEACWW TIHPASKQRS
     EGEKVRVGDD VILVSVATER YLHMAYSKGY MVIASFHQTL WNIQSVSSGS VRTRNMGYVF
     GNDVMRLFHG NDECLTIPEN WSEHPQHNMV IYEGGQAVSQ ARSLWRVELI RMKWHGALIG
     WEQLFRIKHI TSGRYLGVLE NAVQLYHKDK ADFDLTAFVM CQNKDPKKQM LDEKEEEGMG
     TATIQYGETN AFIQHVKTQL WMSYQTSEVT KKGLGKVEEK KAVALKDGHM DDCYTFFMAL
     EEESKSARVI RKCSSVLNRF LKGIDALQNE GQQAADWARV DLNEVLKLME DLIEYFAQPE
     DDQDFEAKQN RFRALRSRQD LFQEEGVLNM ILDTIDKFSL MEALPDFAGI IGEETHMMWE
     EIATYLYLLV AAMIKGNHYN CAQFAAAQRL DWLFGRLSNP QSAEGILDVL YCVLTESPEA
     LNMINEGHIR SVISLLEKVG RDPKVLDVLS SLCEGNGMAV RSSQNLITSY LLPGKDLLLQ
     TAMRDHVSSM MPNVLVGVVD GSALFRRWYF EAEVEHIEKM TKEDPYLRVG WANSVGFKPF
     PGSGDKWGCN GVGDDFYSYG FDGRCVYFAG RGRVVSPKRL EKGDVVGCAL DLNVPELRFS
     VNGRDVGASY RDFNTDGYFF PVMSLSAKVS CRFIFGGDQG RLRFGPPPGF SAAVEAVSGE
     LQISDCLSFG DLPKNVYCGP HTLFTTVEPF VPQPVDISNI ILHHHAEEIH QKFAENLHEL
     WAMRKIELGW SYGETRSEAQ RKHPCLTSFD RLPATEKQYN INLSLDTMKT IEALGYHLIT
     DEPPTRLRPV RLTPNFQQSN GYKPQPLDTH EIVLPDELNP LIEALARNTH NVWAKEKIKR
     GWTFGLSEFV DATQKRSPHL VPYEEVDNRI KEANKESAAE NLRALQLFGI FIEPPAHEHD
     EYAEKEMRAR KDLVRTYRAE ATYAVTSGKW YFEFEILTAG FMKIGWMDVG ASPDTQLGHD
     DHGYAFDGYL GRKWHQGGES YGKEWKIGDV VGCFLDLNDR TISFSLNGEL LLDPSGSEMA
     FDNVMCGDGL VPAMSLGSGQ RGRLNFGQQS NSLKFFTSCG LQEGYEPFCV NMYRMMPMWF
     AKQLPRFEDI SSGSLLEISR IPATGNSPPC LKLTQKTTIT ESGPSEKATM EYIRLSLPVK
     CNESFVRNKD REALRRTMAE YKPRSMSVVS GIRPPAIPQE FQDQGRDRKK SFIGTMLGLK
     DSRDSEDNRS TRSKQPSYEG EHENEPLALR GSLADLPQED RQAAEERLRE MVDREKPQKK
     GILSRLRDTS HSRRKFNRDA KSKDDKSSRL STGKANWRSF DSASVDAASD GAPPAGQKDV
     LASSDMPSSG PGRQLTVRKS SLKKKKKKEQ TVVTMEKRGS APVLDVADPQ QEGDALAMLE
     HSDKVDEYYY GLRIFPGQDP SLVWVGWVTT QYHFYSTSFE RGRVERRCVY AETMGMNQDS
     VEYRNCYMMN AADLLSHVPD VATNTKVSGT LIGCIVDTSV GELSFQVAGQ DTGVRFKLEP
     GAMLFPAAFF TPTTVEILQF ELGRVKYTFP ISAAMFKSCQ KSLVPFCPPR LTVQCLQPVY
     WARVPNETLR TTALKLSDIR GWSVLCDDPV RIMTVYVPEK DESFDILEII EKPIFLDFHR
     QTLNLYCKLT SHGNQKVAHI LCGHVDEDQI MYAIKSHYLS GPMRQGYHDL LIAIHLQTHA
     SARQSMSKEY VIPLCEQLQN QNVFDPDTET RYPQIMGDVY SMLPVMVAEP VKTQFSRDEE
     MKLLPPAINF DALKAYVMSA MESATRHAVM NCRDLIGGDN RNHFEPLMKL FDSLLVIGVF
     DDTELEALLQ MIHPAAFDPS YEPGTTKKGL TEIELEEHVK IQLVNILDHL CDTQLRHRIE
     SLVGFTDGFV GDLQQDQCKR YMDIKQTDMP PAEAAKKTKE FRCPPKEQMF RLLKCKVEKE
     EKEVLFEDEV EYDQCPMAEN LQEQLRDYCA MLVEKIGNTD EPDEEERQSL IETEDGSWVD
     SLARLVVAVP PPPPINEKEL ATKKGTRNFR EMIINMLREW ALGTFIESNE LIRKMFNLLL
     RQYSGIRELQ DAMAQTYVLH ERNNDDVQDF IIYLIQIREL LTVQFEHTEE AILKRGLWKL
     MNNRIFFQHP DLMRLLSVHE NVMSIMMNIL TAQQGAVEHE GEEVKEKTPI KDSSEMVVAC
     SRFLCYFCRT SRQNQKAMFE HLSFLLDNAT MLLARPSLRG SVPLDVAYSS FMDNNELALA
     LKEEELDKVT VYLSRCGLQP NSEMIAKGYP DIGWDPVEGE R
//
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