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Database: UniProt
Entry: U6NT28_HAECO
LinkDB: U6NT28_HAECO
Original site: U6NT28_HAECO 
ID   U6NT28_HAECO            Unreviewed;      1131 AA.
AC   U6NT28;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   07-JUN-2017, entry version 25.
DE   SubName: Full=Ion transport domain containing protein {ECO:0000313|EMBL:CDJ84870.1};
GN   ORFNames=HCOI_01806200 {ECO:0000313|EMBL:CDJ84870.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDJ84870.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDJ84870.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDJ84870.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HF961127; CDJ84870.1; -; Genomic_DNA.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   Pfam; PF00520; Ion_trans; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     29     53       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    344    365       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    395       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    438    461       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    481    504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    557    577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    589    609       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    629    649       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    661    678       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    699    723       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    784    810       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1     58       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      302    467       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      558    821       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      221    244       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1131 AA;  130875 MW;  653910390DF2B401 CRC64;
     MFQIITQEGW TDVVVEILRA TNESMVPFVA IYFVGYHLLV TLIVLSLFVA VILDNLEMDE
     ELKKVKQLKA REQVTSEFPL PKIRDSFTRQ FADDSERCTL ESVNDIEPSV NRSILRRGAY
     IRAQRKVRMR HIGQISSRHI VSSLLDESNR NRALYCDTNQ IIPPLGRGML KSSKGTPMGS
     RSRGFQSMKG KSHLEGMNEN GDVRPTDSAP KKDPKQGEID IKALQQKRAH AEITRNRIEE
     EMRENHPLFD RPLFAVGRDS RLRILCQNIV YAQYSPERID PVTGKQIVLK YKQLHDFIGL
     MTYLDWAMVF VTSLSCWSML FESPWPTTGE NLIFNNPYLQ ITEYLYVVSM TFELMVKVIA
     NGLFFTPKAV VKDVGDIMTF FIYFTSVIYL LWMPSHVEIN SWAQLLMIMR AMRPLRIYTL
     VPHIRRVVVE LCRGFKEILL VTILLIVLMF VFASFGVQIV GGKLAACNDP TITARWAVLF
     IHIYVFIGCM IGLTLFVGVV VANYTENRGT ALLTVDQRRW HDLKARLKMA QPLHVPPKPP
     ESAKLRSYLY DLTLSKAFKQ SFAILVVVNS FTLVVPWNVE EEKQRRNVLF GLTVMSAFCN
     ILFTIEILLK AVAFTVRGFW QSRRNRGDFF ITMLGLTWIV FHFLFQVPAY IAGGINEWKR
     LTYTFGYMVV ILRFFTIAGR KSTLKMLMLT VLMSMVRSLF IIAAMFLLVL FYAYTGVILF
     GMVKYGQAVS KHVNFRNGRE ALVVLFRSVT GEDWNDIMHD CMRSPPFCYW AEGLNYWETD
     CGNYFGAILY FCSFYLIITY IVLNVLVAII MENFSLFYSS EEDALLSYAD IRNFQQVWNY
     VDADQKRSIP TRRVKFLLRL LRGRLEVDPN KDRLLFKHMC YEMERLHNGE DVSFHDVLNM
     LSYRSVDIRK SLQLEELLQR EELEYLIEEE VAKQTIRAWL ESCLRRIKQK QNVGQSESTV
     PTVLPLHRLS CLAPHVPHTP SQHNLVSAHI ISPQAAQNFE SFESRESVEE ENGSKKRQRR
     RNSIPELVGE AKKFMFGSLA KRLEKATETK AGKDRRGTLK QIQMPTYELP DLEENLDEAS
     DSPQERRHSV DTPLSNNPEL LMLNTSTPSV EFNTLEQNQE LHQWWTDLFE L
//
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