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Database: UniProt
Entry: U6NU53_HAECO
LinkDB: U6NU53_HAECO
Original site: U6NU53_HAECO 
ID   U6NU53_HAECO            Unreviewed;      2836 AA.
AC   U6NU53;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   10-MAY-2017, entry version 17.
DE   SubName: Full=Inositol 1 and MIR and Intracellular calcium-release channel and RyR IP3R Homology associated and Ion transport domain containing protein {ECO:0000313|EMBL:CDJ84774.1};
GN   ORFNames=HCOI_00567600 {ECO:0000313|EMBL:CDJ84774.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDJ84774.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDJ84774.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDJ84774.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HF961017; CDJ84774.1; -; Genomic_DNA.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2379   2401       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2413   2430       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2442   2470       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2509   2531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2551   2576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2679   2698       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      130    184       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      257    317       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      324    378       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      425    486       MIR. {ECO:0000259|PROSITE:PS50919}.
SQ   SEQUENCE   2836 AA;  322684 MW;  4DEB164A32D0B771 CRC64;
     MSLPFLRKSS LCMSMDGGNT SLLHFGDIIS LYTEETADLR GFLSTLGLVD DRCIVELRDG
     RPESPPKKFR DCLFKVCPVN RYAAQKQYWT EQKRFISGES TFDDDMMNKL RIAAEKEKEQ
     NELEFRKTQG NVIQYGTTVQ LLHVKSDKYV TVQKNSPAKC ERNAMKVYLD RAGNEGSWFI
     IEPAYKHYVI GDSVAAGNKI SLVPYSVNSQ TSGHVKHQLH LSHFLLKDHQ TAAEVNCLNE
     CTEWQVFMFL LFNENQPDIV KSGDVVRLFH ADQQTFLTLD AIPKTCPPQD VVFLRMTNRP
     SAADATSSRA LWEVQVVQKD AYRGGAAKWR EVYRFKHLAT DMYLTAIPAT SPVKPASNGR
     RASLLHMKTK GEFLAPPPNQ LYADGPESTE ECSSGTYFLV PVKSDFPEAD RKLLFSLDPG
     IMPMNKDVPS KSYVRLQHEA TNTWVHATSA TEKQNLYYSS KNEKGWVRVI CENNRVDKET
     FALLPVHPNE VRDLDFANDA CRALRNFIRH IKSGDPVTKE SINVTIQLLT ECIYFVTNTK
     NHMMDPLQIS DFTPSRDRQK LLREQEVLDQ VFQLLKAPFM PRQGLTEIGP LLSSPSELGE
     TRNEVFKTMF QLCYSLLRYS QVSYRKNQEF LAEKFGQIQE QIGFDLLAED TMTAVLHNNP
     KLLEKYVKTP HVERFVELVR NNRLGKFLDY LADLCVCRGE ANKKVQELIC NSVLSEKHRD
     ILMETKLIDD EVHIGWMGQP LRKLVDLAYS SRKNTSDAEF LDYYRHQLDL LAQMCQEQQY
     LAIDPPPERK LLNISQQLPA DLVLRCMSDS RLPCEVRASF ARLMLHLHVV RGSPLSAIRH
     ARLWTDITNE VKVQSYKTTS VEGYSDGGRA RVGDQFATDV LNTVEDYLNS LRDSYPSGPV
     LHKDAASVAH NKLTFEMVTL AKALAQFGYY TFDNLLTLTE NLLHIVDNSP HSAQTARTVS
     HGMTMIHRVT QSMIGTGTRK IGDSVMKASD KVNIEDTAKA KESRQLLVKT KLTVAEILQF
     VMDVRRDYRI TMALSWFKLN FPCDEDGVLN HTANINERMA HELYEAIYQS SGHELHLDGG
     DGQLLLAILM QMTMSDYPPL TSIALKVLFR HFTQYQELLE DLKQVQLLVS SDDVENYRQV
     DRDLFILKNL TEKSELWVHG DRHHSIDAKD QEHDKTTKMD FEEHSLITSK GFATDEILKA
     VVDIIDEHYM GSRKDCLRLL NQLLISEDRN LAAIALQELS DRTPLIAYPL IRQILVRLKK
     LCYKKDRPDS MNQQLLKNMR VYEVVLEFLS IPYDKKNDFE MPRLITLSHE FLRSFCKGNK
     ENQSRLHKFI SIEKDAKEGT LRVETVEEAA TLVAIFRNNR ELASNVSEDL IAHIVNLIEH
     KSRNAVFLEL LQSLVCIYDK EIETSQDKVA TEICSASDEV RALYVDNASF EQLEQMMQQA
     PPYLDSSHPL KYHIELVRLL ALCTRGKNGS TELKCASEIP MDHIVRVVTS PSCLVEVKTA
     YFQFLLHCYI DTDAEMKDAY KAEYVDSLLH NMLLDVQKLH SELSSTSPST NIAVLEQYIC
     LTVTEILLKF FEKPYSESAK VDIHAHKKMF TAILQQLSIL HASCLKRSQS PKHWYRVDQC
     IKRLRKWAEE NKISVPASIS MPPFSSVPTV KQRWQCAANS ARFISQHSLS MRNRANSLMM
     PGFPNPRQQT DKVANVVTCY HMMIGEFKFY LLPLHSAEGS VLVDVLHTPD LLFPVGSTLR
     EKCAKGAVVT KLIQHCKTLM QNKQDNLCTR VLQTLCRMCS CTKHSLSDQR GRFSIRSHQL
     GQQLRSKLLQ RYFGPHGKSD RLSDGSDGVK SAGLADKDYE VRMEERSLYD IQCRLNDAGA
     SDLVIDIITE EPSREIFLKA IHLAKALLLE GNDKVQQSFY NRLKKKDAHE PFFKAISQRI
     QTAQNRLKSD MMSCNENKPK GASTALTPVS SEHGNGGPGA LFAANHIRHP SLSEISNHSH
     EMTSVPDLSP YQDDERTSDA LPPEVAIIEP ILRVLQLLCE NHNNLLQNFI RKQSDRTNHN
     LVSDTLSFLD TVCGSTKGSL GVFGEIGEHN FSLITQTLAT LTEFCQGPCH ENQNTMAMQE
     NGLNIIISLV LNDIKPLADD HMELALEIKS QASKLLLAIM ESRHDSENAE RVLQNMDNTD
     GGPRQLVHAL TQAYEMAHSK QYEIVQMRRE LLQRANFHDG PTSVVSPLIK TEAVTLPEIS
     VDASGTVSIH DEATKVDMKY VADDASTVDP KEVGHNIYIL AHQLARHSPE LAQCLDPDDD
     KKSVQTRNAL EFYKKHTAQI EIVRQDRTLE RVVFPIHEIC SFLTKETKQN VYNNTERDNQ
     GSKVSEFFDQ WPAMYQEMKW QRKLQDRPYL SACTQRLRLW GRLAFLFAVL VNIIIALYYP
     FETADTGLCA SNPFMYTSSV ISIIFLYSQW DENSSLAKSS NIITAIGAVM FSIAILLISL
     LGVVPALYLI GLAQLANKCI HLVAYASNKG LEDKSWSVRM SDGELHYHIS YLVVCFLGLT
     VHPMLYCLLL FDIVASEETL RNVIASVTRN WQSIILTGLL ALILVYIFSI VGYTFFQRDF
     SLEVDPLEDD TPVATIFTKD PAPDTCSADG GCPIPAPVKE EEKDDKKDDD KKIPSCTTLR
     MCIITTLNWG LRNGGGIGDV LRNVGPDERL FYYRIVYDLS FYVVLIVITL NLIFGVIIDT
     FGDLRTEKND KEDVLKNTCF ICGLERGKFD NRPVTFEDHQ AEEHNLWHYL YFIVWLQIKD
     ETEFTGPESY VAQCVKDRNL DWFPRMQAIS LQDGDSETDQ PEIAAIREQL RQQDQSIRDL
     TASIDDLRQF ILELRS
//
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