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Database: UniProt
Entry: U6PCA9_HAECO
LinkDB: U6PCA9_HAECO
Original site: U6PCA9_HAECO 
ID   U6PCA9_HAECO            Unreviewed;       503 AA.
AC   U6PCA9;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 27.
DE   SubName: Full=Ion transport domain containing protein {ECO:0000313|EMBL:CDJ90416.1};
GN   ORFNames=HCOI_01329300 {ECO:0000313|EMBL:CDJ90416.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDJ90416.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDJ90416.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDJ90416.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HF964803; CDJ90416.1; -; Genomic_DNA.
DR   ProteinModelPortal; U6PCA9; -.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF214; PTHR10037:SF214; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     20     42       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     63     89       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    135    157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    248    268       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    333    360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    372    396       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    462    487       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       22    285       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      338    485       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   503 AA;  58345 MW;  B96852A8C0968992 CRC64;
     MISVCLHTPE TIALWPPLNY AIFANDCIVT LVFLVEAAIH IHHVGLWENE TSYLRAKWSQ
     FDLFMLLMHV LSCALHSYEL FTILVPSLGL VYRPWFGVIR SPRPFIMLRF IRSLVRFKLP
     RNRIKQIIKR SSQQIQNVTI FFMFFMALYA IMGVQLFGRM DYHCVLSGTD PRNVTIADLA
     IPDTMCSQKG EGGYECPDNM VCMKLDMSAH VEGFYGMFND FASSLFTVYM AASQEGWVYV
     LYDCLDTLPS YVAFFYFVTL IFFLAWLVKN VFIAVITETF AEIRVQFSEM WQSNTSASED
     TYTQRLERFE GGWRLVEVDH YSRSIGSPRL LQLIVNSTVF QISMMGLVLL NALINASFVY
     RHDKSDAIRK EIYYYMEICF TVLFNIEALL KVIGYGWKNY VRRGQHKFEL ILCVGSTLNL
     IRPLYNMNIF TYFQVFRIVR LIKASPMLED FVYKIFGPGK KLGGLVIFTM VLLFITSAIS
     LQLFCYVPNL KKFTTFPMVS LFX
//
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