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Database: UniProt
Entry: U6PYH6_HAECO
LinkDB: U6PYH6_HAECO
Original site: U6PYH6_HAECO 
ID   U6PYH6_HAECO            Unreviewed;       531 AA.
AC   U6PYH6;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   10-MAY-2017, entry version 25.
DE   SubName: Full=Potassium channel and Ion transport domain containing protein {ECO:0000313|EMBL:CDJ96598.1};
GN   ORFNames=HCOI_02039800 {ECO:0000313|EMBL:CDJ96598.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDJ96598.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDJ96598.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDJ96598.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
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DR   EMBL; HF967394; CDJ96598.1; -; Genomic_DNA.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003971; K_chnl_volt-dep_Kv9.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01494; KV9CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203,
KW   ECO:0000313|EMBL:CDJ96598.1};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   TRANSMEM    341    360       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    413    434       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    449    467       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    474    495       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       99    198       BTB_2. {ECO:0000259|Pfam:PF02214}.
FT   DOMAIN      272    505       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   531 AA;  59801 MW;  BCF95C02D087EA48 CRC64;
     MAIAISQAVL QHRASIQFGI PGTDTALKFK NYRVTGNMIS GAAQQHKKRL VPLRKTDAMS
     HAERRNFLIL DDVWRSGGSE CFQIIPPGAI GPDGEPMFLR LNIGGTRYML LVDALLRAEP
     SGFLSKFVQL THSARLKVAD AYIAAEDSYF FQRSPVAFEA IFQYYATGVV HRPSEVCPAS
     FLSELDFWRI SHQHVGSCCA DIVPQKREEE KEEEKVDDTT FDNLMFGKVR RRMWTFLERP
     GSSMQAKAFE LSSTLFVAIS VMGLSFGTIP DFQVTHYMPP QNETIVLPNG TVTVVEKVEE
     MRVEHPAFVF TERICIAFFT VEYCLRLFAA PRKLRFALKP LNLVDLLAIV PFYLELLLTL
     CGVDDKKLRD LRWAFLVVRI LRVLRVIRII KLGRFSSGLQ TFGMTLQRSQ KQLQMMTIVL
     LTGVVFFSTM IYFLEKDEDG TPFTSIPAAY WWCIVTMTTV GYGDAVPATT MGKIIASAAI
     MCGVLVLALP ITIIVDNFIK VAQDEQQAEQ TKLDSSRQEL ALQAMLHGDE D
//
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