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Database: UniProt
Entry: U6PYJ0_HAECO
LinkDB: U6PYJ0_HAECO
Original site: U6PYJ0_HAECO 
ID   U6PYJ0_HAECO            Unreviewed;      1424 AA.
AC   U6PYJ0;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-SEP-2017, entry version 25.
DE   SubName: Full=BTB:POZ and Endonuclease exonuclease phosphatase and Peptidase M18 domain containing protein {ECO:0000313|EMBL:CDJ97996.1};
GN   ORFNames=HCOI_02179200 {ECO:0000313|EMBL:CDJ97996.1};
OS   Haemonchus contortus (Barber pole worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Strongylida; Trichostrongyloidea; Haemonchidae; Haemonchinae;
OC   Haemonchus.
OX   NCBI_TaxID=6289 {ECO:0000313|EMBL:CDJ97996.1, ECO:0000313|Proteomes:UP000025227};
RN   [1] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RX   PubMed=23985316; DOI=10.1186/gb-2013-14-8-r88;
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Hunt M., Jackson F., Johnston S.L.,
RA   Kryukov I., Li K., Morrison A.A., Reid A.J., Sargison N.,
RA   Saunders G.I., Wasmuth J.D., Wolstenholme A., Berriman M.,
RA   Gilleard J.S., Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus, a key model
RT   parasite for drug and vaccine discovery.";
RL   Genome Biol. 14:R88.01-R88.16(2013).
RN   [2] {ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|Proteomes:UP000025227};
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:CDJ97996.1, ECO:0000313|Proteomes:UP000025227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ISE/inbred ISE {ECO:0000313|EMBL:CDJ97996.1,
RC   ECO:0000313|Proteomes:UP000025227};
RA   Laing R., Kikuchi T., Martinelli A., Tsai I.J., Beech R.N., Redman E.,
RA   Holroyd N., Bartley D.J., Beasley H., Britton C., Curran D.,
RA   Devaney E., Gilabert A., Jackson F., Hunt M., Johnston S., Kryukov I.,
RA   Li K., Morrison A.A., Reid A.J., Sargison N., Saunders G.,
RA   Wasmuth J.D., Wolstenholme A., Berriman M., Gilleard J.S.,
RA   Cotton J.A.;
RT   "The genome and transcriptome of Haemonchus contortus: a key model
RT   parasite for drug and vaccine discovery.";
RL   Submitted (MAY-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; HF968121; CDJ97996.1; -; Genomic_DNA.
DR   MEROPS; M18.002; -.
DR   Proteomes; UP000025227; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR   CDD; cd14734; SPOP_C; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR000300; IPPc.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   InterPro; IPR034089; SPOP_C.
DR   InterPro; IPR008974; TRAF-like.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF02127; Peptidase_M18; 2.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00128; IPPc; 1.
DR   SMART; SM00061; MATH; 1.
DR   SUPFAM; SSF49599; SSF49599; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS50144; MATH; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000025227};
KW   Endonuclease {ECO:0000313|EMBL:CDJ97996.1};
KW   Exonuclease {ECO:0000313|EMBL:CDJ97996.1};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00489385};
KW   Nuclease {ECO:0000313|EMBL:CDJ97996.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000025227}.
FT   DOMAIN       94    222       MATH. {ECO:0000259|PROSITE:PS50144}.
FT   DOMAIN      268    336       BTB. {ECO:0000259|PROSITE:PS50097}.
SQ   SEQUENCE   1424 AA;  159572 MW;  0B59FA7D5B9505E8 CRC64;
     MCGPIDRGSV VRLSTRSDFR EAVRRSLCEG MSLPRLPIIA GQVAIAPSPA PPPASVPTPS
     AIRVSSLRSD DATASQPKKL EVVSKQATKV TALSTKLEWK IDQFEKLMKL FKNGQNLISR
     QFGVPQAPTV CWELHVYPNG KREEDMNNVS FFLRQVGLQR GEEPIMTEFQ IYALDVSSQR
     VSVCRDTKDF TNQQGRGKFQ VSRDKMAGAL RADGSLLLIC EVEYFTPGSK ISVEPADDEE
     CTLEDVDEKV ELSIRESNRE MWESELFTDC VIKVGCKEIK AHRCVLGQHS PVFRSMFNNE
     SMIEAREGII DIQDAKYESV RAMVEFMYTG SMDTVDSNSV DEVLAIADKY EVLPLKEQCE
     RIISNTITQK NITSIAVFAD TYTATLLKQA VIRYLTVHHK NIIRTPEWRA MKKDRYELAN
     ELLEAVLSAS GDMDEESMNS SSKGPARKRV RRCMDWRVVI ITYNVNMQRA DEDDIEKLLA
     PSIAVKPSIL VIGMQEVSHG ETVVGGTAVT WQRQILEWMS TRSEGMVLLT KTYQMTNQVT
     VYLKRALLPQ IRRIQFRFSR NTMGGLTGHK GSIGVNISLH GGISVVFVES HFIHDVISYD
     KRIAQFHSNK TCCFPEDKEV KATFWLGDLN FRVEKEPEEA LEFIKAKTCP KLLDTSEQLN
     QAIRQKEAFV GYKEQPIHFP PTYRFFVGST EYDLKRTPSW CDRVLFTGDI ISPISYISNE
     HVLVSDHLPV QAVFDLKVPV SSGSNWDVLF EHLPPWYTTV PLISRFQFRH NYWSSRGSYL
     DWAAVYPATI DDCTTPIKWI WIATCSDQTV QNQRYIISVS ITSIPSRFAV FFCRRLLQGS
     SEFFAPPPYS ARTFSCSSFL LNPENMSYEL ASDGKYLGKG TTISMTPSRP EIRREAEEFV
     TFLNRAVTPF HAVQECRERL LQGGFQELHE AAHWDIKPMG KYFVTKNRSA IIAFAVGGAY
     VPGNGFAIVV AHTDSPCLRV KPVSKLQSEK FNQVAVSTYG GGIWRTWFDR DLSVAGEVVF
     RAGDTLARRL INIDQPILYI PNLAIHLTKD RENFNCNNET HLRPILETFA SAGINPFKKD
     SSLGQSEGTK DPRDIVADHH ANFLDLIALA AHTTADQVVD MDLYLYDANP ARIGGIHDEF
     ITGARLDNLV GTYTAMQGLL ESLEDDRHLH DDINIRIAAA FDNEEVGSQT AMGAQSSFTE
     YVLRRLASGG SNPCAFEEAI GRSILISADQ XXXXXXXXXX XXXXXXXXXX XXXXXSQTAM
     GAQSSFTEYV LRRLASGGSN PCAFEEAIGR SILISADQAH AAHPNYVDQH ETNHRPTFHE
     GVVVKVNVNQ RYATTSTTHA VLKQIAAEAN VPLQKVVVRN DSPCGSTVGP ILAARLGIQT
     VDVGCPQLAM HSIREMVDTS SLTQATRLYA TFFNRMRYVL PSLM
//
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