ID U7KEF1_9CORY Unreviewed; 294 AA.
AC U7KEF1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1287_01309 {ECO:0000313|EMBL:ERS44802.1};
OS Corynebacterium sp. KPL1986.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1203619 {ECO:0000313|EMBL:ERS44802.1, ECO:0000313|Proteomes:UP000017151};
RN [1] {ECO:0000313|EMBL:ERS44802.1, ECO:0000313|Proteomes:UP000017151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KPL1986 {ECO:0000313|EMBL:ERS44802.1,
RC ECO:0000313|Proteomes:UP000017151};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Jacobson B., Goguen K.,
RA Pagano E., Lemon K.P., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Corynebacterium sp. KPL1986.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERS44802.1}.
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DR EMBL; AXLS01000002; ERS44802.1; -; Genomic_DNA.
DR RefSeq; WP_023017925.1; NZ_KI515719.1.
DR AlphaFoldDB; U7KEF1; -.
DR STRING; 1203619.HMPREF1287_01309; -.
DR PATRIC; fig|1203619.3.peg.1261; -.
DR HOGENOM; CLU_035117_1_2_11; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000017151; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..294
FT /note="3-hydroxyisobutyrate dehydrogenase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039376602"
FT DOMAIN 6..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 168..288
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 174
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 294 AA; 30443 MW; C38EEF2621AB1231 CRC64;
MTTTPKIAWI GLGAMGAPMA LATAEAGMSV TAYDVSPDSL KAVESHLSVA SNAREAVTGA
DVVAIMVATG AQLDSVLFGD DGVASELKQD TVVLVMATVG PQAIESAAAR LEDVNVRVVD
APVSGGVARA KTGDLLIMVG GESSDVSVVQ PLLNAMAAKS PVVGPKPGDG QRFKIVNQLL
CGVHIAAAAE ALALADSMGL DLTQVHDVLG TGAAASFMFS DRGQRMIDEN FDDVRSALDI
FVKDMGLVSE AAREVHQQVP LSSTAEQLYV RGHREGLGRK DDSITFKLLR GDSD
//
