ID U7KHZ7_9CORY Unreviewed; 594 AA.
AC U7KHZ7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Selenocysteine-specific elongation factor {ECO:0000256|ARBA:ARBA00015953};
DE AltName: Full=SelB translation factor {ECO:0000256|ARBA:ARBA00031615};
GN ORFNames=HMPREF1287_00201 {ECO:0000313|EMBL:ERS45765.1};
OS Corynebacterium sp. KPL1986.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1203619 {ECO:0000313|EMBL:ERS45765.1, ECO:0000313|Proteomes:UP000017151};
RN [1] {ECO:0000313|EMBL:ERS45765.1, ECO:0000313|Proteomes:UP000017151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KPL1986 {ECO:0000313|EMBL:ERS45765.1,
RC ECO:0000313|Proteomes:UP000017151};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Jacobson B., Goguen K.,
RA Pagano E., Lemon K.P., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Corynebacterium sp. KPL1986.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation factor necessary for the incorporation of
CC selenocysteine into proteins. It probably replaces EF-Tu for the
CC insertion of selenocysteine directed by the UGA codon. SelB binds GTP
CC and GDP. {ECO:0000256|ARBA:ARBA00025526}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERS45765.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AXLS01000001; ERS45765.1; -; Genomic_DNA.
DR RefSeq; WP_023017713.1; NZ_KI515719.1.
DR AlphaFoldDB; U7KHZ7; -.
DR STRING; 1203619.HMPREF1287_00201; -.
DR PATRIC; fig|1203619.3.peg.196; -.
DR HOGENOM; CLU_023030_1_1_11; -.
DR OrthoDB; 9803139at2; -.
DR Proteomes; UP000017151; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001514; P:selenocysteine incorporation; IEA:InterPro.
DR CDD; cd04171; SelB; 1.
DR Gene3D; 1.10.10.2770; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR015191; SelB_WHD4.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR004535; Transl_elong_SelB.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00475; selB; 1.
DR PANTHER; PTHR43721:SF22; ELONGATION FACTOR TU, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43721; ELONGATION FACTOR TU-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF09107; SelB-wing_3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:ERS45765.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Protein biosynthesis {ECO:0000313|EMBL:ERS45765.1}.
FT DOMAIN 1..171
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 594 AA; 63718 MW; D17BAAF25CA0E286 CRC64;
MYVTATAGHV DHGKSSLVRA LTDMDPDRWA EEKRRGLTID LGFVWTALPS GADVAFVDVP
GHEKFFGNML AGVGPASVVL FVVAADEGWQ AQSTDHRDAL HALGIEHGII ALTRSDRADD
KRRAEVTAQV RTQFSATPLA DAPIIPVSSH TGEGLADLGA ALDDLVARVP APDTDAPVRL
WIDRAFSVKG AGTVVTGTLS AGTLRTGDAL VLSTVAGDKR VEIRGLHSEN TAQESLGPVT
RAAVNLRGVD AADIHRGDLL LTPGAWRGVD IVDVHRTFGT ALDELPDNLV VHCGTAGIEA
HLRPLSADFA HLRLSRAMPL VILDRLVVRS PGGRHVSAGV EVIDVRPPEL DRRGAARKRA
EALAEHTSFR NPSSYLQRVG YARRADLELD GYDTDATPPG IINFQQWWIA ARQVTRWKEA
LTTALQEHAA ANPLAPGMPR TAALDALGLK EEGLLRLAVA AAHAEESEGL IRLPGHSVDL
GAAEPDVAEL ESRLEKEPFA APEAHELKDL GLSEKELAAA ERAGRLLRLK DGIILLPDAP
DKAREHLSQL EQPFTLSAAR QALGTTRRVA VPLLEYLDAH GITRRGEGGK RTLR
//
