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Database: UniProt
Entry: U7L3K5_9CORY
LinkDB: U7L3K5_9CORY
Original site: U7L3K5_9CORY 
ID   U7L3K5_9CORY            Unreviewed;       566 AA.
AC   U7L3K5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=HMPREF1281_01379 {ECO:0000313|EMBL:ERS52900.1};
OS   Corynebacterium sp. KPL1855.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=1203562 {ECO:0000313|EMBL:ERS52900.1, ECO:0000313|Proteomes:UP000017096};
RN   [1] {ECO:0000313|EMBL:ERS52900.1, ECO:0000313|Proteomes:UP000017096}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KPL1855 {ECO:0000313|EMBL:ERS52900.1,
RC   ECO:0000313|Proteomes:UP000017096};
RG   The Broad Institute Genomics Platform;
RA   Earl A., Ward D., Feldgarden M., Gevers D., Jacobson B., Goguen K.,
RA   Pagano E., Lemon K.P., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA   Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA   Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J.,
RA   McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A.,
RA   Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Corynebacterium sp. KPL1855.";
RL   Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERS52900.1}.
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DR   EMBL; AXLX01000018; ERS52900.1; -; Genomic_DNA.
DR   RefSeq; WP_023024606.1; NZ_KI515743.1.
DR   EnsemblBacteria; ERS52900; ERS52900; HMPREF1281_01379.
DR   PATRIC; fig|1203562.3.peg.1327; -.
DR   Proteomes; UP000017096; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017096};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017096}.
FT   DOMAIN      258    386       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      470    539       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     266    273       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   566 AA;  62631 MW;  8C2E49ABE8A4AD63 CRC64;
     MTEPQANLEA VWRAIVDDLL AQSEQPNSEV PSFSHTQRLY LQLVRPIMMV EGYTLVAAEN
     VNAKEVVENE LGGYISKALT RHLGRPCSFA VTLATPQEPQ PPANPSNSQP APGGASPSGQ
     APSSQPDPQA QHMPPAQTDT SSAQNYVSRP QQTDAAAARG NNNPTAGQAP PNWRSSHAPA
     SLDELAEHYT SQQDYNRQQP EFGGSANAAR IPREAPAHDP NRETSLNPKH TFESFVIGSS
     NRFANGAAVA VAENPARAYN PLFIWGGSGL GKTHLLHAAG NYAQVLHPGL RVKYVSSEEF
     TNDYINSLRD DRQESFKRRY RNLDILMVDD IQFLEGKEST QEEFFHTFNA LHQANKQIIL
     SSDRPPKQLT TLEDRLRTRF EGGLITDIQP PDLETRIAIL MKKAAADGTE VDRSVLELIA
     SRFESSIREL EGALIRVSAY SSLVNEPINV EMAEIALRDL APDSADRQIT AASIMEVTAE
     YFDIDVETLR GAGKKRAVAH ARQLAMYLCR ELTELSLPKI GEQFGGKDHT TVIYADRKIR
     KEMTEKRNTY DEIQSLTQRI KNRGRA
//
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