ID U7MVL7_9CORY Unreviewed; 947 AA.
AC U7MVL7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=CRISPR-associated helicase cas3 {ECO:0000313|EMBL:ERS74209.1};
GN ORFNames=HMPREF1290_00497 {ECO:0000313|EMBL:ERS74209.1};
OS Corynebacterium sp. KPL1989.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1203622 {ECO:0000313|EMBL:ERS74209.1, ECO:0000313|Proteomes:UP000017102};
RN [1] {ECO:0000313|EMBL:ERS74209.1, ECO:0000313|Proteomes:UP000017102}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KPL1989 {ECO:0000313|EMBL:ERS74209.1,
RC ECO:0000313|Proteomes:UP000017102};
RG The Broad Institute Genomics Platform;
RA Earl A., Ward D., Feldgarden M., Gevers D., Jacobson B., Goguen K.,
RA Pagano E., Lemon K.P., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M., Howarth C.,
RA Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C., Pearson M.,
RA Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Sequence of Corynebacterium sp. KPL1989.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERS74209.1}.
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DR EMBL; AXLR01000002; ERS74209.1; -; Genomic_DNA.
DR AlphaFoldDB; U7MVL7; -.
DR PATRIC; fig|1203622.3.peg.479; -.
DR eggNOG; COG1203; Bacteria.
DR HOGENOM; CLU_013924_1_0_11; -.
DR Proteomes; UP000017102; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd09641; Cas3''_I; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041372; Cas3_C.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF18395; Cas3_C; 1.
DR Pfam; PF18019; Cas3_HD; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000017102}.
FT DOMAIN 38..245
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT DOMAIN 313..515
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
SQ SEQUENCE 947 AA; 104785 MW; F5B7526024281D5B CRC64;
MDTTSFLPKS TIDFANNMES WVTNKSHQAK SLWAKSGDES GYLNLPQHLV DSACTAAAVF
DIWVSDSIKQ NLGHHLGISV AQLRALYTFL AGVHDIGKAC KTFQTQLDQL PDYAHLAANV
SDSGLDTTKS TLELGRQKMP HGIVSGVILQ SWLSQHDAKP KLAIWLSSTV DAHHGIASSS
SEQENISRVM DEYPTSWRNV HSELLDSMAE STNFYKIIAA LNKTRSFHAG DAQLLTGLVV
MADWIASNAE AFPMQVTGSQ TERITNGMAA TDLTGPWTTE LPLQNIDHFF TKSFGWPDTF
TARPVQKSMV EIALNIKQPS LFILEGETGV GKTEGAQAAA HVLGHAQQSQ GIYFAAPTMA
TANGLLERTI NWAQQTTEAS SVASLYLAHS KNQLSRPYQE LRFREIGEDR LNPNNSHKTS
GDVVASSWMS GRRRGLLANI VVGTVDQVLM LALQQRYSML RHTALAGKII IFDEVHAYDA
YTSDYLETTL EWLAFYGASV IMMSATLPPQ RRQALIQAYT GASSALAPKA YPLITVANET
ETQYVTPEPT PTNLTAQVHI IGDELTALTT LLQDLLVDGG CALIICNTIA RAQETLAAVE
ETFPGETELH HAGFTARDRT AKEDMLRAQL GPDANRSTTR PFRKIVVATQ VAEQSLDIDA
DVLLTDIAPI DLLIQRLGRV HRHQRPASDR PDQLCNPAMY IRGVHALTPI PEIDSGAMTI
YDPKIILATL LHLPDTFRRP DDIEPLVRAV YEGEQNIPAA WHEVWQTAEE ESCARIERAH
ARSKTYRTCS PFAAKSLERL FERKHQDVIN NNEETGAAQV RDAEPAVEVI PIIGTDYGYT
PWGKKTEILK SSELNYSDAH YLATSTVRLP TRMTRYDRDF DEVITTLERN TPENWSQHFL
LKGQLALQLN AEGSCQLGRF QVCYSNRLGI ECLSDTSNIR VTASNYV
//
